Colloid Lithography-Induced Polydimethylsiloxane Microstructures and their Application to Cell Patterning

Colloidal lithography was used to make a novel array (2-D) of micro-rings, dots, and interconnected-honeycomb structures. These geometries are controlled using the curing temperature-dependent rheological properties of the siloxane elastomer precursor. Serratia marcescens was patterned on the interconnected honeycomb microstructure demonstrating a potential application for microbioanalytical devices, microfluidics, and bio-micro-electromechanical systems. Received 26 August 2005; Revisions requested 23 September 2005; Revisions received 10 November 2005; Accepted 11 November 2005