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1.
William A. Rottschaefer 《Theorie in den Biowissenschaften》2002,121(2):175-203
Summary Proponents of Developmental Systems Theory (DST) argue that it offers an alternative to current research programs in biology
that are built on the historic disjunction between evolutionary and developmental biology. In this paper I illustrate how
DST can be used to account for the acquisition of an important component of moral agency, conscience. Susan Oyama, a major
proponent of DST, has set moral issues outside the compass of DST. Thus, I examine her reasons for restricting DST to non-moral
matters, and argue that they are not decisive. On the positive side, I argue that DST not only is compatible with attempts
to describe and explain moral agency but also aids us in understanding it. In particular, I show how DST can provide a fruitful
perspective for viewing some significant current findings and theories in moral developmental psychology about the acquisition
of conscience. The familiar dichotomies resisted by DST, those between genes and environment, inherited and acquired, innate
and learned, and biological and cultural, have also plagued human developmental psychology, including moral development. By
bringing a DST perspective to the study of moral development, I illustrate how a DST perspective might offer a promising way
to reconceive that phenomenon, and provide some insights into how further work in understanding the development of moral agency
might proceed. Thus, I hope to contribute to the current efforts of proponents of DST to integrate developmental and evolutionary
considerations. 相似文献
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The currently accepted type species of the genusTrichosporon Behrend isT. beigelii. This species has formerly been regarded as identical toT. cutaneum. However, these fungi are now known to represent separate species with different ecology. The first species described inTrichosporon wasT. ovoides, an agent of human white piedra. A neotype strain is designated for this species, while a lectotype strain is indicated forT. cutaneum. The nameT. beigelii is considered as doubtful and consequently cannot be maintained. 相似文献
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David Cheal 《Human ecology: an interdisciplinary journal》1993,21(2):197-213
In Canada, there has been a marked increase in the relative frequency of dual earner families, and especially of dual career families, compared to breadwinner/homemaker families. Effects of this change on the handling of incomes inside the household are examined here. In this paper, quantitative survey data and qualitative data on strategies of financial management are described and analyzed for co-resident couples in Winnipeg. Findings are presented on control over income, financial possession, and access to household money. These findings are interpreted as evidence of a shift in the form of companionate marriage toward greater equality of economic agency. It is suggested that the most common household financial strategy among Canadian couples today is that of flexible shares. 相似文献
5.
Sonia Mannan Jobair Alam K. M. Ashbarul Bari S. M. A. A. Mamun Rehnuma Mehzabin Orin 《Developing world bioethics》2023,23(3):252-259
Informed consent to medical intervention is fundamental in both ethics and law. But in practice it is often not taken seriously in developing countries. This paper provides an appraisal of informed consent practices in Bangladesh. Following a review of the ethical and legal principles of informed consent, it assesses the degree to which doctors adhere to it in Bangladesh. Based on findings of non-compliance, it then investigates the reasons for such non-compliance through an appraisal of informed consent practices in Bangladesh and provides recommendations aimed at improving such practices. The significance of this paper lies in unveiling the interdependence between the ethical and legal traits of informed consent and their ramifications on strengthening the patient-oriented approach of duty to care. 相似文献
6.
Effects of ligand binding on the stability of aldo–keto reductases: Implications for stabilizer or destabilizer chaperones 下载免费PDF全文
Aurangazeb Kabir Ryo P. Honda Yuji O. Kamatari Satoshi Endo Mayuko Fukuoka Kazuo Kuwata 《Protein science : a publication of the Protein Society》2016,25(12):2132-2141
Ligands such as enzyme inhibitors stabilize the native conformation of a protein upon binding to the native state, but some compounds destabilize the native conformation upon binding to the non‐native state. The former ligands are termed “stabilizer chaperones” and the latter ones “destabilizer chaperones.” Because the stabilization effects are essential for the medical chaperone (MC) hypothesis, here we have formulated a thermodynamic system consisting of a ligand and a protein in its native‐ and non‐native state. Using the differential scanning fluorimetry and the circular dichroism varying the urea concentration and temperature, we found that when the coenzyme NADP+ was absent, inhibitors such as isolithocholic acid stabilized the aldo–keto reductase AKR1A1 upon binding, which showed actually the three‐state folding, but destabilized AKR1B10. In contrast, in the presence of NADP+, they destabilized AKR1A1 and stabilized AKR1B10. To explain these phenomena, we decomposed the free energy of stabilization (ΔΔG) into its enthalpy (ΔΔH) and entropy (ΔΔS) components. Then we found that in a relatively unstable protein showing the three‐state folding, native conformation was stabilized by the negative ΔΔH in association with the negative ΔΔS, suggesting that the stabilizer chaperon decreases the conformational fluctuation of the target protein or increase its hydration. However, in other cases, ΔΔG was essentially determined by the delicate balance between ΔΔH and ΔΔS. The proposed thermodynamic formalism is applicable to the system including multiple ligands with allosteric interactions. These findings would promote the development of screening strategies for MCs to regulate the target conformations. 相似文献
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目的
探讨医院病案管理数字化实现的技术和方案。方法 采用了病案数字化管理方式,使用高速扫描仪,进行病案资料的数字化采集;同时配合大型数据库技术和大容量硬盘资料缓存技术,实现病案资料的网络检索、查询和打印输出。结果 病案数字化改变了医院传统病案管理模式,提高了病案的使用率,提高了工作效率。结论 在电子病案实现之前,病案数字化管理是解决当前病案资料在保存与利用、信息安全、数据共享等诸多方面问题的一种实用、有效的管理方式。 相似文献