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Ethanol disrupts the formation of hypochord and dorsal aorta during the development of embryonic zebrafish 总被引:2,自引:0,他引:2
QIAN Linxi WANG Yuexiang JIANG Qiu ZHONG Tao & SONG Houyan Key Laboratory of Molecular Medicine Ministry of Education Shanghai Medical School of Fudan University Shanghai China 《中国科学:生命科学英文版》2005,48(6):608-615
It has been demonstrated that maternal drinking during pregnancy had serious adverse effects on the health of the newborns. Fetal alcohol syndrome (FAS) is the most important developmental abnormality caused by maternal alcohol abuse during pregnancy. Clinically, it is characterized by head and facial ab-normalities, cardiovascular malformation, and perma-nent nervous system damage[1,2]. A lot of experimental models have been developed to study the ethanol’s effects on embryonic development,… 相似文献
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Qian?Linxi Yuexiang?Wang Qiu?Jiang Tao?Zhong Houyan?SongEmail author 《中国科学C辑(英文版)》2005,48(6):608-615
Exposure to ethanol during human embryonic period has severe teratogenic effects on the cardiovascular system. In our study,
we demonstrated that ethanol of gradient concentrations can interfere with the establishment of circulatory system in embryonic
zebrafish. The effective concentration to cause 50% malformations (EC50) was 182.5 mmol/L. The ethanol pulse exposure experiment displayed that dome stage during embryogenesis is the sensitive
time window to ethanol. It is found that 400 mmol/L ethanol pulse exposure can induce circulatory defects in 43% treated embryos.
We ruled out the possibility that ethanol can interfere with the process of hematopoiesis in zebrafish. By employing in situ hybridization with endothelial biomarker (Flk-1), we revealed that ethanol disrupts the establishment of trunk axial vasculature, but has no effect on cranial vessels. Combined
with the results of semi-thin histological sections, the in situ hybridization experiments with arterial and venous biomarkers (ephrinB2, ephB4) suggested that ethanol mainly interrupts the development of dorsal aorta while has little effect on axial vein. Further
study indicated the negative influence of ethanol on the development of hypochord in zebrafish. The consequent lack of vasculogenic
factors including Radar and Ang- 1 partly explains the defects in formation and integrity of dorsal aorta. These results provide important clues to the study
of adverse effects of ethanol on the cardiovascular development in human fetus. 相似文献
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