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A. V. Chekanov A. N. Osipov Yu. A. Vladimirov V. I. Sergienko O. M. Panasenko 《Biophysics》2007,52(1):1-7
Hypochlorite (HOCl/OCl?) and hypobromite (HOBr/OBr?) are shown to react with tert-butyl hydroperoxide with close rate constants (10.8 and 8.9 M?1 s?1, respectively). Using a spin trap α-(4-pyridyl-1-oxide)-N-tert-butyl nitrone, both reactions are shown to proceed through decomposition of the hydroperoxide yielding butylperoxyl [˙OOC(CH3)3] and butoxyl [˙OC(CH3)3] radicals in a ratio depending on the hydroperoxide concentration. Thus, like hypochlorite, hypobromite can generate free radicals in reactions with organic hydroperoxides, which can be important for intensification of free-radical processes, e.g., lipid peroxidation at the chain branching stage. 相似文献
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Paul S Francis Neil W Barnett Trevor A Smith Paul G Spizzirri Xueqin Wang Elmars Krausz 《Luminescence》2005,20(6):442-444
The chemiluminescent oxidation of ammonia with hypobromite in aqueous alkaline solution evokes a broadly distributed emission in the near-infrared region, with intensity maxima at 1055 nm and 1270 nm. 相似文献
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Using MALDI-TOF mass spectrometry, we have shown that leukocytic myeloperoxidase (MPO) in the presence of its substrates (H2O2 and Br?) does not induce any changes in saturated 1,2-dipalmitoyl-sn-glycero-3-phosphocholine. Incubation of liposomes prepared from mono-unsaturated phosphatidylcholine (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine) with the (MPO + H2O2 + Br?) system resulted in formation of bromohydrins as the main products. 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (lysophosphatidylcholine) was the main product of the reaction of polyunsaturated phosphatidylcholine (1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine) with the (MPO + H2O2 + Br?) system. The formation of lysophospholipids as well as of bromohydrins was not observed when the enzyme or one of its substrates (H2O2 or Br?) was absent from the incubation medium, or if an inhibitor of MPO (sodium azide) or hypobromite scavengers (taurine or methionine) were added. Thus, it can be postulated that the formation of bromohydrins as well as lysophospholipids by the (MPO + H2O2 + Br?) system results from reactions of hypobromite formed during MPO catalysis with double bonds of acyl chains of phosphatidylcholine. Such destructive processes may take place in vivo in membrane-or lipoprotein-associated unsaturated lipids in centers of inflammation. 相似文献
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