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Paul Dureus Dahla Louis Anthony V. Grant Thomas V. Bilfinger George B. Stefano 《Cellular and molecular neurobiology》1993,13(5):541-546
| 1. | In a concentration-dependent manner neuropeptide Y was found to be a potent inhibitor of the spontaneous activation of human granulocytes and macrophages as well asMytilus edulis immunocytes. |
| 2. | Neuropeptide Y also inhibited the chemotaxic response of these immunocytes to the chemoattractant f-MLP. |
| 3. | Incubation of both the human and the invertebrate immunocytes in f-MLP (10–9 M) causes activation as noted by random locomotion (chemokinesis). Neuropeptide Y also blocked f-MLP-induced chemokinesis. |
| 4. | The results suggest that neuropeptide Y may, in addition to other functions, serve as an endogenous regulator of immunocyte function. |
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