In vivo effect of diosmin on carrageenan and CCl4-induced lipid peroxidation in rat liver microsomes

The aim of this study was to compare the protective effect of a flavonoid, the 3′5,7-trihydroxy-4′-methoxyflavone 7-rutinoside or diosmin, on liver microsomal lipid peroxidation induced in rats by either carbon tetrachloride or carrageenan. Thirty rats were divided into five groups. Group 1 received no chemical product and was considered as control. Groups 2 and 3 received either an intraperitoneal injection of carrageenan or carbon tetrachloride 48 or 24 hours before killing, respectively. Groups 4 and 5 were treated first with an intraperitoneal injection of diosmin and then by carrageenan (group 4) or carbon tetrachloride (group 5) 48 or 24 hours before killing, respectively. The lipoperoxidant effect of carrageenan and carbon tetrachloride was demonstrated by both significant decreases in polyunsaturated fatty acids, principally 20:4 (n− 6) (p < 0.05) and of vitamin A (p < 0.05) in groups 2 and 3. With diosmin treatment, only thiobarbituric acid reactive substances significantly decreased in group 4, whereas vitamin A level increased. These results could suggest that the effect of diosmin differs with the choice of chemical product used; it seems a better antioxidant against products inducing inflammation. © 1996 John Wiley & Sons, Inc.     

Effect of a Synthetic Flavonoid Derivative,Lew-7/S1 on Phospholipid Model Membranes

Abstract

The effect on model phospholipidic membranes of LEW-7/S1, a synthetic derivative of diosmin, has been investigated by Quasielastic Light Scattering (QLS) and Fourier Transform Infrared Spectroscopy (FT-IR). The results of the first technique show a modification of the phase transition and a decrease of the elastic modulus of the bilayer in the presence of the drug. The FT-IR results indicate interactions in the polar head and the aqueous interface regions.     

大孔吸附树脂分离纯化香叶木苷

比较了D-101、D-140、AB-8、XAB-8、D312、聚酰胺等6种吸附树脂对蓬子菜中活性成分香叶木苷diosmin的吸附和洗脱条件,在静态吸附研究的基础上,进行了动态实验,并且利用二次吸附对该成分进行了纯化。结果表明AB-8树脂对diosmin的吸附量大、吸附速度快、解吸容易、富集分离效果好。利用聚酰胺进行二次纯化,得到纯度95%以上的diosmin。     

挥发油提取后薄荷地上部分的化学成分

中药薄荷为唇形科植物薄荷(M entha haplocalyxB riq.)的干燥地上部分,又称接骨草、野薄荷。薄荷性凉味辛,具有疏散风热、清头目和透疹之功效,常用于治疗风热感冒、风温初起、头痛、目赤、喉痹、口疮、风疹、麻疹及胸肋胀闷等症[1],且对消化、中枢、生殖及呼吸系统等有明显的药