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Under conditions of the open-field test, we demonstrated that bemitil and benzimidazole injected intraperitoneally into rats
in doses of 50 to 150 mg/kg suppress horizontal and vertical (motor and research) activities, as well as decrease the frequencies
of episodes of grooming, defecation, and urination. Possible mechanisms underlying modifications of behavioral phenomena triggered
by the above agents are discussed.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 1, pp. 85–90, January–February, 2006 相似文献
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O.?I.?KolotilovaEmail author V.?B.?Pavlenko A.?M.?Kulichenko I.?O.?Korenyuk Yu.?O.?Fokina 《Neurophysiology》2005,37(3):205-212
In experiments on five awake cats, we studied the effects of bemitil, a drug possessing psychostimulatory, antidepressive,
and actoprotector properties (peroral introduction, 50 mg/kg), on the activity of neurons of the aminergic cerebral systems.
Eleven noradrenergic (NA-ergic) neurons of the locus coeruleus (LC) and 11 serotonergic (ST-ergic) neurons of the nuclei raphe (NR) were examined. A control experimental series was carried out on 8 NA-ergic neurons of the LC and 8 ST-ergic neurons
of the NR. Bemitil was found to exert opposite effects on the impulse activity of NA-ergic and ST-ergic brainstem neurons;
it suppressed impulsation of LC neurons and increased the spiking frequency of NR neurons within certain time intervals after
its introduction. Analysis of EEG showed that bemitil decreased the spectral power of the delta and theta activities, which
was accompanied by behavioral relaxation.
Neirofiziologiya/Neurophysiology, Vol. 37, No. 3, pp. 235–243, May–June, 2005. 相似文献
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Gamma T. V. Korenyuk I. I. Baevsky M. Yu. Ravaeva M. Yu. Pavlenko V. B. 《Neurophysiology》2002,34(2-3):130-132
We studied the effects of application of bemitil, 2-ethylbenzimidazole hydrochloride, and 2-methyl benzimidazole hydrochloride in 10-5 and 10-4 M concentration on identified molluscan neurons. It was found that the agents exert clear neurotropic effect, which, as we assume, are determined by their influence on different types of ion channels. 相似文献
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