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Isovaleric acidemia (IVA) is a rare autosomal recessive disorder caused by a deficiency of isovaleryl-CoA dehydrogenase encoded by IVD gene. In this case study we report the first Saudi IVA patients from a consanguineous family with a novel transversion (p.G362V) and briefly discuss likely phenotype–genotype correlation of the disease in the Saudi population. We explored the functional consequences of the mutation by using various bioinformatics prediction algorithms and discussed the likely mechanism of the disease caused by the mutation.  相似文献   
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The growth of the Spanish‐speaking Hispanic population in the United States has fostered the creation of an extensive Spanish‐language media industry. In particular, while the Spanish‐language media industry has expanded in correspondence with the growth of the Spanish‐speaking Hispanic population in the United States, Spanish‐language television has done so in order to capitalize on the consumer and commercial value of the population. In doing so, we argue in this article that the Spanish‐language media industry serves to dislocate Chicanos in US society by not promoting their sociocultural and ethnolinguistic identity.  相似文献   
3.
This article draws from the experiences of women, located in different countries, whose scholarship expresses a commitment to anti-racism and social justice. What are the challenges they face? How do they negotiate multiple commitments? Anti-racism scholars are border crossers and ethical leaders with a deep sense of care. Their experiences suggest that one does not necessarily have to engage in activism ‘out there’. The very commitment to anti-racism, as a scholar, becomes a form of social justice work. The ability to have a transformative impact both inside and outside of the academe enriches their sense of fulfilment as scholars.  相似文献   
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Research groups are the cornerstone of scientific research, yet little is known about how these groups are formed and how their organization is influenced by the gender of the research group leader. This represents an important gap in our understanding of the processes shaping gender structure within universities and the academic fields they represent. Here, we report the results of an email survey sent to department chairs and discipline‐specific listservs. We received responses from 275 female and 175 male research group leaders. Most respondents were biologists (n = 328) but psychology (n = 27), chemistry (n = 16), physics (n = 32), and mathematics (n = 30) were also relatively well represented. We found that men were self‐reported as overrepresented in research groups in the physical sciences, particularly at later career stages. Within biology, male and female group leaders reported supervising a disproportionate number of same‐gender trainees (students and postdoctoral fellows), particularly early in their careers. These self‐reported patterns were driven primarily by gender‐based differences in the pool of students applying to their research groups, while gender differences in acceptance rates played a seemingly smaller role. We discuss the implications of our results for women continuing into the professoriate and for the recruitment of young scientists into research groups.  相似文献   
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Abstract: Statistics is one of the most important yet difficult subjects for many ecology and wildlife graduate students to learn. Insufficient knowledge about how to conduct quality science and the ongoing debate about the relative value of competing statistical ideologies contribute to uncertainties among graduate students regarding which statistical tests are most appropriate. Herein, we argue that increased education of the available statistical tests alone is unlikely to ameliorate the problem. Instead, we suggest that statistical uncertainties among graduate students are a secondary symptom of a larger problem. We believe the root cause lies in the lack of education on how to conduct science as an integrated process from hypothesis creation through statistical analysis. We argue that if students are taught to think about how each step of the process will affect all other steps, many statistical uncertainties will be avoided.  相似文献   
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ABSTRACT The controversy over the use of null hypothesis statistical testing (NHST) has persisted for decades, yet NHST remains the most widely used statistical approach in wildlife sciences and ecology. A disconnect exists between those opposing NHST and many wildlife scientists and ecologists who conduct and publish research. This disconnect causes confusion and frustration on the part of students. We, as students, offer our perspective on how this issue may be addressed. Our objective is to encourage academic institutions and advisors of undergraduate and graduate students to introduce students to various statistical approaches so we can make well-informed decisions on the appropriate use of statistical tools in wildlife and ecological research projects. We propose an academic course that introduces students to various statistical approaches (e.g., Bayesian, frequentist, Fisherian, information theory) to build a foundation for critical thinking in applying statistics. We encourage academic advisors to become familiar with the statistical approaches available to wildlife scientists and ecologists and thus decrease bias towards one approach. Null hypothesis statistical testing is likely to persist as the most common statistical analysis tool in wildlife science until academic institutions and student advisors change their approach and emphasize a wider range of statistical methods.  相似文献   
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Action to pursue the circular economy (CE) transition is burgeoning in the government and the private sector. Does this action signal that CE is a distinct field of research with a unique disciplinary identity? This article argues that CE has reached field status, through its own epistemic communities characterized by increasingly shared methodological perspectives and normative ideals, and through institutionalized knowledge development through research journals and authority structures. The recent growth of CE research points toward more contextualized and nuanced operationalizations of the concept, evidence that the field is approaching a threshold state of maturity. Drawing on observations from academic literature and discussions with researchers and experts, we trace the process by which CE has arrived at the status of a field. The article concludes with reflections on research directions.  相似文献   
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