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1.
Linda Partridge 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2010,365(1537):147-154
Human life expectancy in developed countries has increased steadily for over 150 years, through improvements in public health and lifestyle. More people are hence living long enough to suffer age-related loss of function and disease, and there is a need to improve the health of older people. Ageing is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable. This view has been reinforced by the realization that ageing is a disadvantageous trait that evolves as a side effect of mutation accumulation or a benefit to the young, because of the decline in the force of natural selection at later ages. However, important recent discoveries are that mutations in single genes can extend lifespan of laboratory model organisms and that the mechanisms involved are conserved across large evolutionary distances, including to mammals. These mutations keep the animals functional and pathology-free to later ages, and they can protect against specific ageing-related diseases, including neurodegenerative disease and cancer. Preliminary indications suggest that these new findings from the laboratory may well also apply to humans. Translating these discoveries into medical treatments poses new challenges, including changing clinical thinking towards broad-spectrum, preventative medicine and finding novel routes to drug development. 相似文献
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Two new compounds, derriscoumaronochromone (1) and cis-3,4′-dihydroxy- 5,7-dimethoxyflavan (2), as well as trans-4'-O-methylcatechin (3) were isolated from Derris laxiflora, The structures of these compounds were determined by analysis of their spectroscopic data. 相似文献
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Nataly Mancette Rijensky Netta R. Blondheim Shraga Eilon Barnea Nir Peled Eli Rosenbaum Aron Popovtzer Solomon M. Stemmer Alejandro Livoff Mark Shlapobersky Neta Moskovits Dafna Perry Eitan Rubin Itzhak Haviv Arie Admon 《Molecular & cellular proteomics : MCP》2020,19(8):1360-1374
Highlights
- •Sufficient tumor tissues are often unavailable large HLA peptidome discovery.
- •Using patient derived xenograft (PDX) tumors can overcome this limitation.
- •The large PDX HLA peptidomes expand significantly those of the original biopsies.
- •The HLA peptidomes of the PDX tumors included many tumor antigens.
6.
Uichiro Kotera Toru Kodama Yasuji Minoda Koichi Yamada 《Bioscience, biotechnology, and biochemistry》2013,77(8):1315-1325
In the course of study on the mechanism of the tartaric acid formation from 5-ketogluconic acid, a new intermediary substance with mauve color to Abdel-Akhel and Smith’s reagent was isolated from intact cell culture liquid. The chemical structure of this substance was determined as 1,2-dihydroxyethyl hydrogen L(+) tartrate from the results of hydrolysis experiments and from the identifications of the constituents of the molecule, and named “pretaric acid.” Tartaric acid was evidently produced from pretaric acid by intact cell culture. Clearly, then, pretaric acid appears to be an intermediate in the formation of tartaric acid from 5-ketogluconic acid. The authors assumed that in the formation of pretaric acid from 5-ketogluconic acid, a Baeyer-Villiger type oxidation occurred. 相似文献
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B. Friebe M. C. Cermeño F. J. Zeller 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1987,73(3):337-342
Summary C-banding patterns and nucleolar activity were analyzed in Dasypyrum villosum, its added chromosomes to hexaploid wheat and the hexaploid amphiploid Triticum dicoccum-D. villosum. Two different populations of the allogamous species D. villosum (2n= 14, VV) from Greece and Italy were analyzed showing a similar polymorphism for C-banding pattern. Six of the seven addition lines were identified by their characteristic C-banding pattern. No polymorphism between both members of each added alien chromosome was found. Furthermore, nucleolar activity and competition were studied by using silver staining procedure. In D. villosum only one chromosome pair, A, was found to be responsible for organizing nucleoli. The results obtained in the amphiploid and in the addition lines demonstrate that nucleolar activity is restricted to SAT-chromosomes 1B and 6B of wheat, while those of D. villosum remain inactive. 相似文献
9.
中国的红树林 总被引:1,自引:0,他引:1
我国红树林主要分布在热带及亚热带沿海盐滩和河川出口的冲积盐性土上,包括24个科,47种,属于东方群系。从广西钦州湾开始经北海港,沿雷州半岛的海安分为两支,一支往南经海南岛的儋县新英港,向东经琼山县的东寨港和文昌县的清澜港,沿着东海岸至崖县的三亚港,又折向北到达东方县的八所港;另一支向东北经湛江的赤坎,阳江的海陵岛,台山的上下川岛,中山的三灶岛,新会的崖门,再沿海岸往北至福建的福鼎和台湾的新竹港。根据我国红树林的主要构成种类、外貌、生境,大致可分为3大群系和10个群落。(1) 矮灌木群系——这个群系多见于纬度稍高的海滩前缘,包括海榄雌群落和桐花树群落。这些群落在演替上处于前期阶段。(2) 高大稠密灌木群系——这个群系由于气温、年降雨量的差异和土壤性质的不同,组成这个群系的种类也有不同,不过都是以红树族的种类为建群种,它包括4个群落:红树群落、红海兰群落和角果木群落,这些群落在演替上属于中期阶段。(3) 乔木群系——这个群系主要分布在海南岛东北和东部海岸,所在地一般地势较高,前缘地带每日潮涨仍有海水浸淹。后缘地带只有每月大潮时才有海水到达,土壤比较固结,它包括木榄群落、海莲和尖瓣海莲群落、海桑群落及半红树林水椰群落。这些群落在演替上是处于后期阶段。组成我国红树林的种类大多数都具有较高的经济价值,如角果木是优质单宁的原料,有些种类经过发酵处理成为高营养的饲料和肥料。此外,沿海浮游生物的产量有红树林比无红树林的地带高达7倍,因此加强对红树林的经营和保护应采取积极态度和有效措施。 相似文献
10.
中国繁缕属的一些分类问题 总被引:8,自引:1,他引:7
研究了36种中国产繁缕属(Stellaria)植物,根据模式材料或仅根据原描述,将已合格发表的1组、1系、12种、4变种和1变型首次归并到有关各类,依次列举入异名录中,其中有1移属。讨论了各种错误鉴定,同时对于选择性状、设想进化过程和分布记录均有讨论。 相似文献