排序方式: 共有2条查询结果,搜索用时 109 毫秒
1
1.
Sea Cucumbers Triterpene Glycosides, the Recent Progress in Structural Elucidation and Chemotaxonomy
Vladimir I. Kalinin Alexandra S. Silchenko Sergey A. Avilov Valentin A. Stonik Alexey V. Smirnov 《Phytochemistry Reviews》2005,4(2-3):221-236
Triterpene glycosides are characteristic metabolites of sea cucumbers (Holothurioidea, Echinodermata). Majority of the glycosides
belong to holostane type (lanostane derivatives with 18(20)-lactone). Carbohydrate chains of these glycosides contain xylose,
glucose, quinovose, 3-O-methylglucose and 3-O-methyl sylose. During the last 5 years, main investigations were focused on holothurians belonging to the order Dendrochirotida
collected in the North Pacific, North Atlantic, Antarctic and in subtropical waters. The glycosides of holothurians belonging
to the order Aspidochirotida have also been studied. The most uncommon structural features of carbohydrate chains of new glycosides
were: (1) the presence of quinovose as fifth terminal monosaccharide unit and the presence of two quinovose residues; (2)
the presence of glucose instead of common xylose as fifth terminal monosaccharide unit; (3) trisaccharide carbohydrate chain;
(4) the presence of two 3-O-methylxylose terminal monosaccharide units; (5) the presence of sulfate group at C-3 of quinovose residue. New glycosides
without lactone or with 18(16)-lactone and having shortened side chains have also been isolated. The presence of 17α and 12α-hydroxyls,
which are characteristic for glycosides from holothurians belonging to the family Holothuriidae (Aspidochirotida) in glycosides
of dendrochirotids confirms parallel and relatively independent character of evolution of glycosides. All three families belonging
to the order Aspidochirotida: Holothuriidae, Stichopodidae and Synallactidae have similar and parallel trends in evolution
of the glycosides carbohydrate chains, namely from non-sulfated hexaosides to sulfated tetraosides. Sets of aglycones in glycosides
from holothurians belonging to the genus Cucumaria (Cucumariidae, Dendrochirotida) are specific for each species. The carbohydrate chains are similar in all representatives
of the genus Cucumaria. 相似文献
2.
Nguyen Xuan Cuong Le Thi Vien Le Hoang Tran Thi Hong Hanh Do Thi Thao Nguyen Van Thanh Nguyen Hoai Nam Do Cong Thung Phan Van Kiem Chau Van Minh 《Bioorganic & medicinal chemistry letters》2017,27(13):2939-2942
Using various chromatographic separation techniques, eight triterpene diglycosides (1–8), including four new compounds namely stichorrenosides A–D (1–4), were isolated from a methanol extract of the Vietnamese sea cucumber S. horrens. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, 1D and 2D NMR. Their in vitro cytotoxic activity against five human cancer cell lines, Hep-G2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma), was evaluated using SRB methods. Stichorrenoside D (4), stichoposide A (5), and 3β-O-[β-d-xylopyranosyl-(1→2)-β-d-xylopyranosyl]-23S-acetoxyholost-7-ene (7) showed strong cytotoxicity on all five tested cancer cell lines, whereas significant effect was observed for stichorrenoside C (3) and stichoposide B (6). 相似文献
1