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1.
Benjamin C. Blum Weiwei Lin Matthew L. Lawton Qian Liu Julian Kwan Isabella Turcinovic Ryan Hekman Pingzhao Hu Andrew Emili 《Molecular & cellular proteomics : MCP》2022,21(1):100189
Metabolism is recognized as an important driver of cancer progression and other complex diseases, but global metabolite profiling remains a challenge. Protein expression profiling is often a poor proxy since existing pathway enrichment models provide an incomplete mapping between the proteome and metabolism. To overcome these gaps, we introduce multiomic metabolic enrichment network analysis (MOMENTA), an integrative multiomic data analysis framework for more accurately deducing metabolic pathway changes from proteomics data alone in a gene set analysis context by leveraging protein interaction networks to extend annotated metabolic models. We apply MOMENTA to proteomic data from diverse cancer cell lines and human tumors to demonstrate its utility at revealing variation in metabolic pathway activity across cancer types, which we verify using independent metabolomics measurements. The novel metabolic networks we uncover in breast cancer and other tumors are linked to clinical outcomes, underscoring the pathophysiological relevance of the findings. 相似文献
2.
The red-striped soft scale insect Pulvinaria tenuivalvata (Newstead) (Hemiptera: Coccidae) started to infest sugarcane plants (Saccharum officinarum L.) in different districts in Egypt during the last decade. The percentage of infestation was recorded in El-Wakf area, Qena Governorate (Naghhamadi mill zone) Upper Egypt in some fields. There are three levels of infestation, low, intermediate and high. From these fields, samples were selected for physical and chemical studies. The results obtained show that the stalks of infested plants decreased in weight, the sugar content (glucose and sucrose) drastically reduced and as the percentage of infestation increased the percentage of glucose and sucrose content significantly decreased. The primary and secondary humidity and the cellulose content also increased in the healthy plants compared to the infested ones. All the physical character of the infested plants was significantly affected in comparison with the healthy ones. 相似文献
3.
Water sustainability indices have been recently used to measure the sustainability of water resources within a catchment. Developing a sustainability index involves various steps, some of which have uncertainties associated with them. For the recently developed West Java Water Sustainability Index (WJWSI), three sources of uncertainties were identified, namely uncertainties in the thresholds of non-categorical indicators and sub-indicators, in the weighting schemes, and in the aggregation methods. This paper presents the uncertainty and sensitivity analysis of WJWSI, based on the application of WJWSI to Citarum catchment in West Java, Indonesia. The results of the uncertainty analysis, measured by the coefficient of variation of the thresholds and the sub-indices, indicates that minimum thresholds of Land Use Changes, Coverage, Education, Poverty, Health Impact and Sanitation, and the maximum threshold of Water Quality have higher variation when compared to variation of the other thresholds. The results of the sensitivity analysis, measured by the correlation coefficients between the final index and the thresholds, indicate that changes in the thresholds of WJWSI indicators have not significantly affected the sub-index values of most indicators and sub-indicators. The sensitivity analysis also concluded that either the equal or non-equal weighting scheme can be used for future use of the aggregation of WJWSI indicators and sub-indicators, as changes from equal to non-equal weighting scheme did not significantly affect the final index. However, it was found that the final index values were most sensitive to the aggregation method used (i.e. arithmetic and geometric methods), shown by the significant changes in the final index value when the aggregation method was changed from arithmetic to geometric. The uncertainty and sensitivity analysis presented in this study will not just assist in the efficient use of the WJWSI, but will also help undertake similar analysis for other indices. 相似文献
4.
Kristel Van Steen Nadia Tahri Geert Molenberghs 《Biometrical journal. Biometrische Zeitschrift》2004,46(2):187-202
Until recently, the most common parametric approaches to study the combined effects of several genetic polymorphisms located within a gene or in a small genomic region are, at the genotype level, logistic regressions and at the haplotype level, haplotype analyses. An alternative modeling approach, based on the case/control principle, is to regard exposures (e.g., genetic data such as derived from Single Nucleotide Polymorphisms – SNPs) as random and disease status as fixed and to use a marginal multivariate model that accounts for inter‐relationships between exposures. One such model is the multivariate Dale model. This model is based on multiple logistic regressions. That is why the model, applied in a case/control setting, leads to straightforward interpretations that are similar to those drawn in a classical logistic modeling framework. (© 2004 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim) 相似文献
5.
Abstract Low concentrations (e.g. 2 × 10−6 M) of an imidazole derivative anti-fungal agent, miconazole, were lethal for the Gram-negative, facultative aerobic pathogen Neisseria gonorrhoeae grown either alone or in mixed culture with the yeast Candida albicans . Electron microscopic observation of Neisseria cells exposed to miconazole showed the presence of blebs in the outer wall and areas of separation between the wall and the cytoplasmic membrane. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE) of cell lysates did not reveal differences in major outer membrane proteins between the treated and the untreated cells of any one strain. Imidazole derivatives are frequently used in the treatment of candidiasis. Our in vitro results show that low concentrations of one of them, miconazole, can be bactericidal for N. gonorrhoeae , a bacterium that can colonise sites of the human body where Candida is often found. 相似文献
6.
水洞沟遗址的环境与地层 总被引:11,自引:2,他引:9
水洞沟第四纪地层可与萨拉乌苏河组上段对比。水洞沟遗址包含有新石器和旧石器晚期文化,其旧石器晚期文化发生在距今20,000多年至10,000多年间的黄土状粉砂土中,即发生在末次冰期主冰期的干冷环境下,比发育在距今约35,000—50,000年间的萨拉乌苏河旧石器文化为晚。 相似文献
7.
Analysis of nine characteristics on 1,205 males and 932 females from 12 tribes or groups of tribes indicated a poor relationship between morphology and language, as well as moderate agreement with the variability expected considering geography only. Two samples in the Xingu area studied during an interval of half a century (1897-1947) showed remarkable similarity. The conformity of the Caingang morphology with those of other tribes and the distinctiveness of the Xavante and Tenetehara has been amply confirmed. 相似文献
8.
Multiple discriminant analysis is a useful multivariate technique in vegetation studies that can be employed for several purposes, even if the underlying statistical assumptions are not satisfied. An example of application of this method is discussed: multiple discriminant analysis was successfully used for evaluating the predictivity of forest types defined by numerical classification of vegetation data with respect to soil variables.Species nomenclature follows Pignatti (1982) for vascular plants and Augier (1966) for mosses.The research has been supported by the IDROSER (Bologna, Italy) and by the Italian C. N. R. (Grant no. 83.02548.04, resp. Prof. A. Pirola). We wish to thank Prof. E. Feoli, Prof. E. van der Maarel, Prof. L. Orlóci and Prof. A. Pirola for suggestions. We are also indebted to Dr N. Filippi who analyzed the soil samples. 相似文献
9.
毛叶丁香罗勒精油的化学成分分析 总被引:1,自引:0,他引:1
西双版纳引种栽培的毛叶丁香罗勒精油用Finnigan-4510型毛细管色谱/质谱/计算机联用方法进行了化学成分分析,共分离了26个成分,鉴定了其中的16个成分,占全精油含量的98.5%。主要成分是:丁香酚(80.33%);罗勒烯(12.80%);β-毕橙茄烯(4.24%)。 相似文献
10.
Karsten Pedersen Carola Holmström Anna-Kerstin Olsson Amelie Pedersen 《Archives of microbiology》1986,145(1):1-8
A budding coccoid bacterium, (CH1), a Vibrio sp. and a Pseudomonas sp. were investigated for factors governing their attachment to glass surfaces in static batch culture and laminar flow continuous culture systems. An analysis of variance showed that the three species exhibited very different responses. For CH1 attachment was dependent on cell density, incubation time and nutrient concentration. The Vibrio sp. was affected by nutrient concentration while the attachment of the Pseudomonas sp. was independent of cell density, incubation time and nutrient concentration. A comparison of attachment to hydrophilic and hydrophobic surfaces showed that attachment of the Vibrio sp. and CH1 to hydrophilic surfaces was 3 and 10 times greater respectively than to hydrophobic surfaces while Pseudomonas attached in equal numbers to both surfaces. The continuous culture system with defined flow hydrodynamics and growth conditions at steady state revealed a random sampling effect 3 times smaller than the batch culture system did. When the biofilm development of Pseudomonas sp. was followed during 46 h at different fluid shear under laminar and turbulent flow conditions, the former biofilm reached 3.3·108 cells·cm-2 and the latter 8.2·107 cells·cm-2.Non-common abbreviation NSS
Nine salt solution 相似文献