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Evolution of chromosome bands: Molecular ecology of noncoding DNA 总被引:25,自引:0,他引:25
Gerald P. Holmquist 《Journal of molecular evolution》1989,28(6):469-486
Summary Giemsa dark bands, G-bands, are a derived chromatin character that evolved along the chromosomes of early chordates. They
are facultative heterochromatin reflecting acquisition of a late replication mechanism to repress tissue-specific genes. Subsequently,
R-bands, the primitive chromatin state, became directionally GC rich as evidenced by Q-banding of mammalian and avian chromosomes.
Contrary to predictions from the neutral mutation theory, noncoding DNA is positionally constrained along the banding pattern
with short interspersed repeats in R-bands and long interspersed repeats in G-bands. Chromosomes seem dynamically stable:
the banding pattern and gene arrangement along several human and murine autosomes has remained constant for 100 million years,
whereas much of the noncoding DNA, especially retroposons, has changed. Several coding sequence attributes and probably mutation
rates are determined more by where a gene lives than by what it does. R-band exons in homeotherms but not G-band exons have
directionally acquired GC-rich wobble bases and the corresponding codon usage: CpG islands in mammals are specific to R-band
exons, exons not facultatively heterochromatinized, and are independent of the tissue expression pattern of the gene. The
dynamic organization of noncoding DNA suggests a feedback loop that could influence codon usage and stabilize the chromosome’s
chromatin pattern: DNA sequences determine affinities of → proteins that together form → a chromatin that modulates → rate
constants for DNA modification that determine → DNA sequences. Theories of hierarchical selection and molecular ecology show
how selection can act on Darwinian units of noncoding DNA at the genome level thus creating positionally constrained DNA and
contributing minimal genetic load at the individual level.
Presented in part at the FEBS Symposium on Genome Organization and Evolution, held in Crete, Greece, September 1–5, 1986 相似文献
3.
Here we describe a new short retroposon family of rodents. Like the primate Alu element consisting of two similar monomers,
it is dimeric, but the left and right monomers are different and descend from B1 and ID short retroposons, respectively. Such
elements (B1-dID) were found in the genomes of Gliridae, Sciuridae, Castoridae, Caviidae, and Hystricidae. Nucleotide sequences
of this retroposon can be assigned to several structural variants. Phylogenetic analysis of B1-dID and related sequences suggests
a possible scenario of B1-dID evolution in the context of rodent evolution.
Received: 30 August 1999 / Accepted: 20 March 2000 相似文献
4.
We conducted comprehensive sequence analysis of 5′ flanking regions of primate Alu elements. Information contents were computed and frequencies of 1024 pentanucleotides were measured to approximate the location
of a characteristic sequence and to specify its pattern(s), which may be involved in the integration of Alu elements into their host genomes. A large number of samples was used, the wide region of the 5′ end of Alu elements was analyzed, and comparisons were made among different subfamilies. Through our analyses, ``TTTTAAAAA' or ``(T)
m
(A)
n
' can be stated as a candidate for the characteristic sequence pattern, which resides around the region 5 to 20 base pairs
upstream of the 5′ end of Alu elements. This characteristic sequence pattern was more prominent in the sequences of younger Alus, which is a strong indication that the sequence pattern has a role at the time of Alu integration.
Received: 10 May 1999 / Accepted: 1 October 1999 相似文献
5.
J. M. Hernández C. S. Hernández C. P. Giner V. Donat J. Hernández-Yago 《Molecular & general genetics : MGG》1999,262(2):207-211
We report the identification and characterization of Ψ3Tom20, a novel processed pseudogene of the human Tom20 (hTom20) gene,
which is 96.2% similarity with the hTom20 cDNA and is 5′ and 3′ truncated. In addition, we present the complete characterization
of Ψ1Tom20 and Ψ2Tom20, the two other recently reported members of this pseudogene family. Comparison of the sequences of
Ψ3Tom20 with that of the previously reported Ψ2Tom20 revealed and corrected an error in the previously determined sequence
of Ψ2Tom20. A detailed analysis of these three pseudogenes, including their flanking regions, is presented. It suggests they
probably arose from mRNAs that were polyadenylated at different sites. Possible mechanisms involved in their integration as
retroposons are also discussed.
Received: 29 October 1998 / Accepted: 7 May 1999 相似文献
6.
Y. Quentin 《Journal of molecular evolution》1989,28(4):299-305
Summary A new method of analyzing phylogenetic relations among members of sequence family (Quentin 1988) discriminates at least six possible B1 subfamilies in the mouse genome. Several additional and independent observations suggest that these grouping have evolutionary significance, and that successive waves of fixation of new variants occur during rodent lineage history. We have reason to believe that, in a genome, the founder sequences of different families of retroposons are in competition with regard to the amplification/fixation process. 相似文献
7.
William Bains 《Journal of molecular evolution》1986,23(3):189-199
Summary I have analyzed a collection of published human Alu sequences. The compiled sequences show several unexpected features, including a uniform pattern of divergence from their consensus sequence, a mutual divergence that is not correlated with their age, and common features in the genomic DNA flanking the 5 ends of the elements. I suggest that the Alu family of sequences derives from a large pool of precursors and not from a single precursor similar to the family consensus sequence, and that new elements integrate into the genome selectively at oligo-A-rich sites. 相似文献
8.
The Alu family developed through successive waves of fixation closely connected with primate lineage history 总被引:29,自引:0,他引:29
Y. Quentin 《Journal of molecular evolution》1988,27(3):194-202
Summary A new method of analyzing phylogenetic relations among members of the sequence family is presented and applied to human Alu sequences upon which work has been published. This method, based upon a correspondence analysis, works with large samples and yields easily interpretable graphical representations. Results obtained argue in favor of a new evolutionary scheme for Alu sequences, implying successives waves of amplification/fixation closely connected to primate lineage history. 相似文献
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Recent rapid generation of genomic sequence data has allowed many researchers to perform comparative analyses in various mammalian species. However, characterization of transposable elements, such as short interspersed repetitive elements (SINEs), has not been reported for several mammalian groups. Because SINEs occupy a large portion of the mammalian genome, they are believed to have contributed to the constitution and diversification of the host genomes during evolution. In the present study, we characterized a novel SINE family in the anteater genomes and designated it the MyrSINE family. Typical SINEs consist of a tRNA-related, a tRNA-unrelated and an AT-rich (or poly-A) region. MyrSINEs have only tRNA-related and poly-A regions; they are included in a group called t-SINE. The tRNA-related regions of the MyrSINEs were found to be derived from tRNAGly. We demonstrate that the MyrSINE family can be classified into three subfamilies. Two of the MyrSINE subfamilies are distributed in the genomes of both giant anteater and tamandua, while the other is present only in the giant anteater. We discuss the evolutionary history of MyrSINEs and their relationship to the evolution of anteaters. We also speculate that the simple structure of t-SINEs may be a potential evolutionary source for the generation of the typical SINE structure. 相似文献