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The significance of a special kind of VE-cadherin-based, desmoplakin- and plakoglobin-containing adhering junction, originally
identified in certain endothelial cells of the mammalian lymphatic system (notably the retothelial cells of the lymph node
sinus and a subtype of lining endothelial cells of peripheral lymphatic vessels), has been widely confirmed and its importance
in the formation of blood and lymph vessels has been demonstrated in vivo and in vitro. We have recently extended the molecular
and structural characterization of the complexus adhaerens and can now report that it represents a rare and special combination of components known from three other major types of
cell junction. It comprises zonula adhaerens proteins (VE-cadherin, α- and β-catenin, protein p120ctn, and afadin), desmosomal plaque components (desmoplakin and plakoglobin), and tight-junction proteins (claudin-5 and ZO-1)
and forms junctions that vary markedly in size and shape. The special character and the possible biological roles of the complexus adhaerens and its unique ensemble of molecules in angiogenesis, immunology, and oncology are discussed. The surprising finding of claudin-5
and protein ZO-1 in substructures of retothelial cell-cell bridges, i.e. structures that do not separate different tissues
or cell layer compartments, suggests that such tight-junction molecules are involved in functions other than the “fence” and
“barrier” roles of zonulae occludentes.
This work was supported by a grant from the Deutsche Forschungsgemeinschaft (DFG grant MO 345/5-2).
This study is part of a thesis presented to the Faculty of Medicine of the University of Heidelberg, Germany, to fulfil the
requirements of the doctoral degree (MD) of the first author. 相似文献
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