全文获取类型
收费全文 | 268篇 |
免费 | 12篇 |
国内免费 | 6篇 |
专业分类
286篇 |
出版年
2023年 | 3篇 |
2022年 | 3篇 |
2021年 | 4篇 |
2020年 | 9篇 |
2019年 | 11篇 |
2018年 | 6篇 |
2017年 | 8篇 |
2016年 | 10篇 |
2015年 | 9篇 |
2014年 | 16篇 |
2013年 | 26篇 |
2012年 | 8篇 |
2011年 | 16篇 |
2010年 | 12篇 |
2009年 | 13篇 |
2008年 | 17篇 |
2007年 | 14篇 |
2006年 | 15篇 |
2005年 | 8篇 |
2004年 | 8篇 |
2003年 | 17篇 |
2002年 | 18篇 |
2001年 | 5篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1998年 | 2篇 |
1997年 | 3篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1990年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1980年 | 1篇 |
排序方式: 共有286条查询结果,搜索用时 15 毫秒
1.
2.
《Free radical research》2013,47(2):224-231
AbstractThis study measured the influence of ingesting quercetin on plasma measures for oxidative stress and antioxidant capacity. Male and female subjects (n = 1002) varying in age (18–85 years) and body mass index (BMI) (16.7–52.7 kg/m2) were studied. Subjects were randomized to one of three groups using double-blinded methods: placebo, 500 mg or 1000 mg quercetin/day with 125 mg or 250 mg vitamin C/day, respectively. Pre- and post-study fasting blood samples show that plasma quercetin increased in a dose-responsive manner. The pattern of change in plasma F2-isoprostanes, oxidized low density lipoprotein, reduced glutathione, ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) did not differ between supplementation groups or after adjustment for gender, age, BMI and disease status. In summary, quercetin supplementation over 12 weeks in doses of 500 mg or 1000 mg/day significantly increased plasma quercetin levels, but had no influence on several measures of oxidative stress and antioxidant capacity. 相似文献
3.
4.
Ol’ha O. Brovarets’ 《Journal of biomolecular structure & dynamics》2020,38(10):2817-2836
AbstractThis paper focuses on the comprehensive conformational analysis of the quercetin molecule with a broad range of the therapeutic and biological actions. All possible conformers of these molecule, corresponding to the local minima on the potential energy hypersurface, have been obtained by the sequential rotation of its five hydroxyl groups and also by the rotation of its (A?+?C) and B rings relatively each other. Altogether, it was established 48 stable conformers, among which 24 conformers possess planar structure and 24 conformers – nonplanar structure. Their structural, symmetrical, energetical and polar characteristics have been investigated in details. Quantum-mechanical calculations indicate that conformers of the quercetin molecule are polar structures with a dipole moment, which varies within the range from 0.35 to 9.87 Debay for different conformers. Relative Gibbs free energies of these conformers are located within the range from 0.0 to 25.3?kcal·mol?1 in vacuum under normal conditions. Impact of the continuum with ε?=?4 leads to the decreasing of the Gibbs free energies (–0.19–18.15?kcal·mol?1) and increasing of the dipole moment (0.57–12.48?D). It was shown that conformers of the quercetin molecule differ from each other by the intramolecular specific contacts (two or three), stabilizing all possible conformers of the molecule – H-bonds (both classical ОН…О and so-called unusual С′Н…О and ОН…С′) and attractive van-der-Waals contacts О…О. Obtained conformational analysis for the quercetin molecule enables to provide deeper understanding of the ‘structure-function’ relationship and also to suggest its mechanisms of the therapeutic and biological actions.Communicated by Ramaswamy H. Sarma 相似文献
5.
Aims
Dietary flavonoid intake shows a significant inverse association with mortality from coronary heart disease, incidence of myocardial infarction and stroke. Quercetin is one of the most common flavonoids in our diet and has several favorable biological activities. Quercetin glucosides, which are enzymatically trans-glycosylated isoquercitrin, have high water-solubility and bioavailability compared with quercetin. Here, we investigated the effects of quercetin glucosides on collateral development in a murine hindlimb ischemia model.Main methods
We induced hindlimb ischemia in 24- to 32-week-old male C3H/HeJ mice by resecting the right femoral artery. Then, 0.5% carboxymethyl cellulose (control) or quercetin glucosides (100 mg/kg/day) were administered daily by gavage. Blood flow was monitored weekly by laser Doppler imaging.Key findings
Recovery of blood flow to the ischemic leg was significantly enhanced by quercetin glucosides (blood flow ratio at 4 weeks: control, 0.57 ± 0.11; quercetin glucosides, 0.95 ± 0.10, p < 0.05). Furthermore, anti-CD31 immunostaining revealed that quercetin glucosides increased capillary density in the ischemic muscle (control, 200 ± 24/mm2; quercetin glucosides, 364 ± 41/mm2, p < 0.01). Quercetin glucosides did not promote tumor growth. The beneficial effect of quercetin glucosides was abrogated in eNOS-deficient mice.Significance
These results suggest that quercetin glucosides may have therapeutic potential to promote angiogenesis in ischemic tissue. 相似文献6.
The Fn14 and TWEAK are the receptor and ligand respectively and their mutual recognition and binding was reported to induce
pathogenesis of cancer and chronic autoimmune diseases. We had identified Fn14 as a novel target of low linear energy transfer
(LET) ionizing radiation in mice population. In the present study we generated the novel homology model of human Fn14,
optimized its energy and validated for authenticity by checking Ramachandran plot and also by calculating the RMSD. Based on
our earlier findings with Hippophae rhamnoides, a group of flavonoids and tannins were screened for their docking potential with
Fn14 at the site where its natural ligand TWEAK was binding. The comparative docking analysis showed that the order of docking,
from best to least, was Genistein, Rutin, Gallic acid ethyl ester and Quercetin, respectively. The findings predicted the radiomodifying
action of flavonoids and tannins. The study has immediate applications in development of non-toxic drugs/
nutraceuticals that may protect human population from harmful effects of radiation in various situations, such as nuclear accidents,
occupational exposure, diagnosis or radiotherapy. 相似文献
7.
Sayaka Nakashima Zhe Liu Yuya Yamaguchi Shunya Saiki Shintaro Munemasa Toshiyuki Nakamura Yoshiyuki Murata Yoshimasa Nakamura 《Biochemistry and Biophysics Reports》2016
3,4-Dihydroxyphenylacetic acid (DOPAC) is one of the colonic microflora-produced catabolites of quercetin 4′-glucoside (Q4′G). Although the interaction of DOPAC with cellular proteins might be involved in its biological activity, the actual proteins have not yet been identified. In this study, we developed a novel tag-free DOPAC probe to label the targeted proteins by the copper(I)-catalyzed azide alkyne cycloaddition (CuAAC) and verified its efficacy. Various labeled proteins were detected by the DOPAC probe with the azide labeled biotin and a horseradish peroxidase (HRP)-streptavidin complex. Furthermore, a pulldown assay identified Keap1 and aryl hydrocarbon receptor (AhR) as the target proteins for the phase 2 enzyme up-regulation. 相似文献
8.
Sasa Savic Silvio Keckes Zivomir Petronijevic 《Biocatalysis and Biotransformation》2016,34(5):226-235
Horseradish peroxidase is a well-known member of the peroxidase family that catalyzes oxidation of flavonoids and phenolic substrates to free phenoxyl or semiquinone radicals. Aim of this study was to investigate in vitro oxidation of quercetin by horseradish peroxidase in the presence of l-cysteine as nucleophilic agent, and its influence on previously formed semiquinone- and quinone-type metabolites. The obtained results showed that in the reaction without l-cysteine several products were present, such as quercetin quinone methide, phloroglucinol carboxylic acid, protocatechuic acid, as well as quercetin heterodimer and derivates of quercetin heterodimer. On the other hand, in the presence of l-cysteine only three products were obtained, quercetin quinone methide and two new isomeric mono-cysteine derivatives of quercetin with mass exp. m/z 420.04?±?0.1 [quercetin?+?cysteine–H]– (theor. m/z 420.0389 [quercetin?+?cysteine–H]–). 相似文献
9.
Munkhzul Ganbold Yasuhiro Shimamoto Farhana Ferdousi Kenichi Tominaga Hiroko Isoda 《Biochemistry and Biophysics Reports》2019
Quercetin (QCT) and isorhamnetin (ISO), natural flavonoids, were both shown to possess antifibrotic activity in in vivo and in vitro models of hepatic fibrosis. Although ISO is a direct metabolite of QCT differing by a methyl group, it has been reported to be absorbed more adequately and eliminated slower than QCT after oral administration. Our aim of the study was to investigate biological effect of mono-methylated QCT derivatives against fibrosis using rat hepatic stellate cells (HSC-T6). All test derivatives were synthesized from QCT. HSC-T6 cells were induced by TGFβ and treated with derivatives followed by cell proliferation assay, immunofluorescence staining of αSMA, and gene expression analysis of fibrosis markers. All compounds showed a dose- and time-dependent antiproliferation effect. ISO, 3-O-methylquercetin (3MQ), and rhamnetin (RHA) reduced αSMA mRNA; 3MQ prevented the augmentation of collagen I mRNA; and compounds, except azaleatin and 3MQ, reduced Timp1 mRNA expression in TGFβ-induced HSCs. In conclusion, each compound had singular effect against different features of fibrosis depending on the position of methyl group although the further mechanism of action of compounds during fibrosis development remains to be investigated. These findings suggest that antifibrotic effect of quercetin can be enhanced by adding methyl group on functionally important position. 相似文献
10.
目的:探讨槲皮素对宫颈炎模型大鼠的治疗效果。方法:采用阴道注入苯酚胶浆制备大鼠宫颈炎模型,观察不同剂量(10μmol·L~(-1)、100μmol·L~(-1))槲皮素对大鼠白细胞总数、中性粒细胞数和比例影响,并对实验大鼠宫颈进行病理组织学和超微结构观察(观察细胞膜、线粒体及细胞核结构变化)。结果:槲皮素处理组白细胞总数下降,中性粒细胞计数和百分比均明显降低,与宫颈炎模型组比较差异有统计学意义(P0.05)。病理组织学观察结果显示槲皮素处理组炎症细胞数量较宫颈炎模型组减少,电镜观察结果也表明槲皮素处理组宫颈细胞超微结构损害程度依次减轻,胞核内染色质固缩情况减轻,逐渐可看到连续的核膜结构。结论:槲皮素能明显减轻宫颈组织充血水肿,对宫颈炎模型大鼠有一定的治疗作用。 相似文献