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A role for chemokine signaling in neural crest cell migration and craniofacial development 总被引:1,自引:0,他引:1
Eugenia C. Olesnicky Killian Denise A. Birkholz Kristin Bruk Artinger 《Developmental biology》2009,333(1):161-172
Neural crest cells (NCCs) are a unique population of multipotent cells that migrate along defined pathways throughout the embryo and give rise to many diverse cell types including pigment cells, craniofacial cartilage and the peripheral nervous system (PNS). Aberrant migration of NCCs results in a wide variety of congenital birth defects including craniofacial abnormalities. The chemokine Sdf1 and its receptors, Cxcr4 and Cxcr7, have been identified as key components in the regulation of cell migration in a variety of tissues. Here we describe a novel role for the zebrafish chemokine receptor Cxcr4a in the development and migration of cranial NCCs (CNCCs). We find that loss of Cxcr4a, but not Cxcr7b, results in aberrant CNCC migration defects in the neurocranium, as well as cranial ganglia dysmorphogenesis. Moreover, overexpression of either Sdf1b or Cxcr4a causes aberrant CNCC migration and results in ectopic craniofacial cartilages. We propose a model in which Sdf1b signaling from the pharyngeal arch endoderm and optic stalk to Cxcr4a expressing CNCCs is important for both the proper condensation of the CNCCs into pharyngeal arches and the subsequent patterning and morphogenesis of the neural crest derived tissues. 相似文献
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Characterisation of human craniofacial syndromes and studies in transgenic mice have demonstrated the requirement for Fgf signalling during morphogenesis of membrane bone of the cranium. Here, we report that Fgf activity is also required for development of the oro-pharyngeal skeleton, which develops first as cartilage with some elements subsequently becoming ossified. We show that inhibition of FGF receptor activity in the zebrafish embryo following neural crest emigration from the neural tube results in complete absence of neurocranial and pharyngeal cartilages. Moreover, this Fgf signal is required during a 6-h period soon after initiation of neural crest migration. The spatial and temporal expression of Fgf3 and Fgf8 in pharyngeal endoderm and ventral forebrain and its correlation with patterns of Fgf signalling activity in migrating neural crest makes them candidate regulators of cartilage development. Inhibition of Fgf3 results in the complete absence of cartilage elements that normally form in the third, fourth, fifth, and sixth pharyngeal arches, while those of the first, second, and seventh arches are largely unaffected. Inhibition of Fgf8 alone has variable, but mild, effects. However, inhibition of both Fgf3 and Fgf8 together causes a complete absence of pharyngeal cartilages and the near-complete loss of the neurocranial cartilage. These data implicate Fgf3 and Fgf8 as key regulators of cartilage formation in the vertebrate head. 相似文献
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M. Pickford 《Human Evolution》1988,3(6):449-460
An important constraint on the evolution of primate skeletons is the isometric relationship which exists between skeletal
weight and body weight. The evolution of primate skulls during the Tertiary and Quaternary periods indicates that redeployment
of bone mass took place largely within the skull (i.e. between proximate ossifying centres) and that the major vector was
from the splanchnocranium towards the neurocranium. This vector of bone mass redeployment accords well with the general treand
within primates of increased encephalisation over time. There are however, several interesting examples of vectors which were
oriented in the opposite sense, in particular in the robust australopithecine lineage, in which the emphasis on bone mass
deployment was towards the splanchnocranium and away from the neurocranium. A fuller understanding of skeletal isometry, and
a wider application in comparative anatomy may throw much light on the evolution of skeletal systems, and it may resolve somelong-standing
debates. Among these may be identification of the selection pressures which have led to dental and alveolar reduction inHomo sapiens sapiens (bone mass redeployment into the neurocranium) and perhaps an explanatation for some types of osteoporosis in old people
whose body weight decreases may result in isometric skeletal mass decreases (for every 100 gms muscle tissue loss, there will
be about 7 gms of bone tissue loss). 相似文献
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With the exception of the work of Schultz (1960), cranial growth in Ateles is not well documented. This paper describes the results of a detailed quantitative study of cranial ontogeny in male and female Ateles geoffroyi. Using Euclidean Distance Matrix Analysis (EDMA), local areas of form change due to growth within spider monkey crania are identified. We found substantial change local to the zygomatic region in the face, identified mediolaterally directed changes in the palate, detected relatively larger amounts of change local to the anterior neurocranium compared to the posterior neurocranium, and demonstrate a greater amount of basicranial growth along a mediolateral axis than previously reported. Cranial sexual dimorphism is also examined. A. geoffroyi is noted for being monomorphic, and we found a general similarity between male and female cranial forms at all developmental ages. However, differences in overall cranial size between the sexes were found in the oldest subadult age group but not between male and female adults. This difference suggests that A. geoffroyi females attain their adult cranial form slightly before males and implies a pattern of earlier onset of female maturity relative to males. © 1993 Wiley-Liss, Inc. 相似文献
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