Are There Circadian Variations of Polymorphonuclear Phagocytosis in Man?

Eleven male subjects were investigated to detect a possible circadian rhythm of the polymorphonuclear phagocytosis. Both cell activity and serum opsonins were studied for numerical detection of granulocytes having ingested at least one particle and for the mean number of ingested particles per cell. No significant temporal differences (ANOVA and cosinor) were found.     

Is there modal opponency in the thermal senses?

1. 1.The sensations evoked by pairs of distinct thermal stimuli applied to the back of the hand were studied in 17 volunteer subjects. Four stimulus combinations were used; neutral-cold (NC), neutral-neutral (NN), neutral-warm (NW), and cold-warm (CW).

2. 2.The subjects were first asked to estimate the magnitude of the thermal sensations evoked by the thermal stimuli. On average, the four pairs were reported as increasing magnitude in the following order: NC, CW, NN, and NW, seeming to suggest that the subjects experienced the cold-warm combination as a composite sensation of cold and warmth intermediate between pure cold and pure warmth.

3. 3.When asked only to detect the presence of a cold stimulus, the subjects performed as well for the CW combination as for the CN combination. This second result indicates that the reported composite magnitude of CW does not result from a true opponency of cold and warmth but from a cognitive combination of distinct sensations of cold and warmth.

Structure of bone in the skulls of Neanderthal fossils

Close inspection of surface bone in skulls of Neanderthal man reveals weathering cracks extensive enough in one specimen, La Chapelle-aux-Saints, to allow preliminary analysis of major patterns of orientation and to make inferences about functional relationships of structures. The fine structure of the bone of the brow ridges is very different from the rest of the skull in the two adults examined, having a peculiar vermiculate surface pattern. Weathering cracks do not appear in this region. This indicates that Neanderthal brow ridges are not closely related to normal mechanical forces such as chewing exertion. It may, however, give further support to theories of Neanderthal brow ridges as protection for the eyes. The localized structure of bone often differs from region to region, and offers new possibilities for the analysis of both contemporary and fossil forms.     

In vitro culture of the strobilar stage of Echinococcus granulosus from protoscoleces of human, camel, cattle, sheep and goat origin from Kenya and buffalo origin from India

Protoscoleces from human, camel, cattle, sheep, goat (all from Kenya) and buffalo (from India) hydatid cysts were cultured under identical conditions in vitro using the diphasic culture system of Smyth (1979b). Organisms from all sources grew and segmented in culture. Genital anlagen developed in all cultured worms but further genital differentiation occurred only in cultures of cattle (testes) and camel (testes and genital pore) material. The possible significance of these results is discussed in relation to the general epidemiology of hydatid disease and the potential infectivity of the different strains to man.     

Effect of atropine on plasma gastrin and somatostatin concentrations during sham feeding in man

The purpose of these studies was to measure circulating gastrin and somatostatin concentrations during sham feeding in humans and to evaluate the effect of two doses of intravenous atropine on circulating concentrations of these peptides. Gastric acid and bicarbonate secretion and pulse rate were also measured. Sham feeding increased plasma gastrin concentrations by approximately 15 pg/ml but had no effect on plasma somatostatin-like immunoreactivity (SLI). A small dose of atropine (5 micrograms/kg) augmented plasma gastrin concentrations during sham feeding significantly (P less than 0.01), but did not affect plasma SLI. Atropine also significantly inhibited gastric acid secretion and gastric bicarbonate secretion (by 62% and 52%, respectively), but pulse rate was not affected. A larger dose of atropine (15 micrograms/kg intravenously) suppressed plasma gastrin concentrations significantly compared to the smaller 5 micrograms/kg atropine dose (P less than 0.02), so that plasma gastrin concentrations when 15 micrograms/kg atropine was given were not significantly different from those during the control study. 15 micrograms/kg atropine reduced gastric acid and bicarbonate secretion by 81% and 66%, respectively, and also increased pulse rate by 15 min-1. These studies indicate that small doses of atropine enhance vagally mediated gastrin release in humans, probably by blocking a cholinergic inhibitory pathway for gastrin release. Although the nature of this cholinergic inhibitory mechanism is unclear, we found no evidence to incriminate somatostatin. Our finding that the larger dose of atropine reduced serum gastrin concentrations compared with the smaller dose suggests that certain vagal-cholinergic pathways may facilitate gastrin release.     

Mugharet el'Aliya: Affinities of an enigmatic north African Aterian maxillary fragment

Objectives

This study uses a virtual framework to examine the left maxillary fragment of the juvenile fossil from Mugharet el'Aliya, Morocco, found in association with an Aterian lithic industry. Previously, this fossil had been ascribed to modern humans or the Neanderthal lineage based on its “archaic”/“Neanderthal-like” features and apparent large size. Here, we conducted a novel 3D shape comparative analysis of the maxillary fragment to clarify its taxonomic affinities with regard to its size and ontogeny.

Materials and Methods

Eighty Computed Tomography and surface scans representing ontogenetic samples of Homo sapiens and Homo neanderthalensis were used to capture species-specific differences. The toolkit of geometric morphometrics in combination with surface registration and an elastic iterative closest point algorithm were used to create a dataset of meshes with an identical number of corresponding vertices for the maxillae. Multivariate statistics were applied to Procrustes superimposed coordinates derived from the vertices of this dataset.

Results

Our analysis showed affinities of the Mugharet el'Aliya individual with our H. sapiens sample, especially with a subadult individual from Qafzeh. No size-independent affinities with Neanderthals of comparable dental age could be identified.

Discussion

Our results add to the evidence connecting fossils from western Asia, especially Qafzeh and Skhul, and the North African Aterian. Furthermore, Mugharet el'Aliya adds to our knowledge of the ontogenetic development of adult morphology that is frequently used to characterize hominin groups, for example, Neanderthals and modern humans.     

Gingival eruption sequences of permanent teeth in early hominids.

Gingival eruption of the permanent teeth of Australopithecus, Paranthropus, and early Homo, diagnosed from enamel scratches and facets, is similar save for two sequences: eruption of the canines relative to the premolars which may be sexually dimorphic; and agenesis of M3 with delayed eruption of M2, first seen in Homo at two million years. Gingival eruption sequences are similar also for early and modern Homo, except that in some individuals today M3, M2, M1 and I2 take longer to form and emerge through the gingiva as functioning teeth. Probably, from two million years to the present in the evolutionary history of Homo dental development slowed-down. More and more of ontogeny has been taken over for eruption.     

Hommes modernes en Asie septentrionale

The huge asiatic area does not show clear cut traditions but only fundamental tendencies proper to the human mind considered in its whole evolution mechanism. These tendencies are both clear and powerful: lightness of the skulls, technical blanks lighter, bone tools, pendants, and high mobility. The cultural European categories cannot be applied as such since the anthropological units were fuzzy, just like the huge steppes where they have developed. Europe just represents marginal caricatures and fixed of these general movements acting like waves perpetual and powerful.     

A new discovery of Neanderthal settlements in Turkey: Sürmecik open-air campsite in Western Anatolia

Western Anatolia is the poorest region in terms of Turkey's Palaeolithic finds. In the past years, only a few Palaeolithic artefacts were known from the surface in the provinces of İzmir, Manisa, Kütahya and Afyonkarahisar in western Anatolia. After the fossil Homo erectus skull fragment was found in the travertine deposits in Kocabaş (Denizli) in 2002, the importance of the region more increased. After this important discovery, Dr. Kadriye Özçelik started a Palaeolithic survey in Denizli and found a large number of chipped stone tools from the Lower and Middle Palaeolithic periods. Nevertheless, the last important Palaeolithic discovery in the region was made in Sürmecik (Banaz-Uşak) in 2015. This is an open-air campsite belonging to the Middle Palaeolithic period. Here is also a mining area where a mining operation is conducted. The chipped stone artefacts of the Sürmecik Palaeolithic open-air campsite come from a clay layer between hematite and limonite deposits under a travertine layer of about 4.5–5 meters in thickness. Faunal remains represent mostly by equids species. All stages of Mousterian culture are clearly visible in this open-air campsite. Sürmecik is the richest middle Palaeolithic open-air campsite in Turkey. The 83,002 lithic pieces were collected in the excavations carried out in 2016 and 2017. It is thought that the lithic assemblage will exceed 100,000 with the ongoing studies. The group of bifacial leaf points in this collection is seen in Turkey for the first time. Four master thesis studies started on the lithic material of Sürmecik. It is planned to take some samples for dating analysis along with ongoing studies.