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1.
A robust method for selection of variables with the greatest discriminatory power is presented in the paper. The method deals with the two groups of data problem. An application of the method to some respiratory disease data and comparisons with classical procedures are given, also. 相似文献
2.
The advantage of using terrestrial isopods in toxicity studies is that a battery of parameters can be tested at different levels of biological complexity. Feeding parameters for example link organism level response to potential ecological consequences but a problem with using feeding parameters in toxicity tests with terrestrial isopods is their high variability. The aim of our study was to set benchmark values for feeding parameters for isopod Porcellio
scaber (Isopoda, Crustacea) in laboratory-controlled experiments. In the work presented here, the daily feeding rate of the central 50% of the control population of Porcellio
scaber and a correlation between feeding rate and isopod weight were set. Values outside these ranges need additional evaluation to increase the relevance of test outcomes. We suggest using benchmark values for feeding parameters as well as the coefficient of variation (a) to identify animals with altered feeding parameters with respect to controls, and (b) to assess the data quality in each experiment. 相似文献
3.
Post-mortem human subjects (PMHS) are frequently used to characterize biomechanical response and injury tolerance of humans to various types of loading by means of instrumentation installed directly on the skeleton. Data extracted from such tests are often used to develop and validate anthropomorphic test devices (ATDs), which function as human surrogates in tests for injury assessment. Given that the location and orientation of installed instrumentation differs between subjects, nominally similar measurements made on different PMHS must be transformed to standardized, skeletal-based local coordinate systems (LCS) before appropriate data comparisons can be made. Standardized PMHS LCS that correspond to ATD instrumentation locations and orientations have not previously been published. This paper introduces anatomically-defined PMHS LCS for body regions in which kinematic measurements are made using ATDs. These LCS include the head, sternum, single vertebrae, pelvis, femurs (distal and proximal), and tibiae (distal and proximal) based upon skeletal landmarks extracted from whole body CT scans. The proposed LCS provide a means to standardize the reporting of PMHS data, and facilitate both the comparison of PMHS impact data across institutions and the application of PMHS data to the development and validation of ATDs. 相似文献
4.
H. Tanida W. Hohenboken 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1987,75(1):157-164
Summary Methods for calculating the probability of detecting a carrier of a recessive gene by utilizing matings among related individuals are presented for single and litter bearing species. The confidence level for detection of heterozygosity depends upon: (1) the genetic relationship between mates, (2) the number of mates per male and the number of offspring per mate, (3) whether an estimate of recessive gene frequency before selection is available and (4) the magnitude of that frequency. Methods of computing probability of heterozygosity vs homozygosity utilizing Bayes theorem also are presented. In the conventional progeny test method, a sire initially is assumed heterozygous before calculations are made, but no prior information concerning his probable genotype is utilized. In the method using Bayes theorem, prior sources of information from relatives or from estimates of population allele frequency are utilized. This method gives the exact probability that a sire is not a carrier, given prior information and that he produces all normal offspring. These methods could be used in any sexually reproducing species to identify not only detrimental genes but beneficial genes as well. 相似文献
5.
9-β-
-Arabinofuranosyl-2-fluoroadenine (F-ara-A) and 9-β-
-arabinofuranosyladenine (ara-A) are purine nucleoside analogues which are incorporated into nucleic acids. This study demonstrates the mutagenic properties of F-ara-A and ara-A and provides evidence for mechanisms by which the arabinosyl nucleosides induce mutation. At the drug dosages that evoked exponential cell killing, F-ara-A and ara-A caused a significant increase in the number of 6-thioguanine-resistant mutants in Chinese hamster ovary cells. Southern analyses showed that 15 of 16 drug-induced mutants had lost all or part of the HPRT gene, whereas no loss of the gene was found in 4 spontaneous mutants. We conclude that both F-ara-A and ara-A induced mutation predominantly by causing deletion of genetic method. The remarkable frequency of gene deletion among these drug-induced mutations is discussed with respect to possible mechanisms of action of arabinosyl nucleosides in mutational studies. 相似文献
6.
In this note we outline some recent results on the development of a statistical testing methodology for inverse problems involving partial differential equation models. Applications to several problems from biology are presented. The statistical tests, which are in the spirit of analysis of variance (ANOVA), are based on asymptotic distributional results for estimators and residuals in a least squares approach.Research supported in part under grants NSF MCS 8504316, NASA NAG-1-517, and AFOSRF-49620-86-C-0111. Part of this research was carried out while the first author was a visiting scientist at the Institute for Computer Applications in Science and Engineering (ICASE), NASA Langley Research Center, Hampton, VA, which is operated under NASA contracts NASI-18107 and NASI-18605 相似文献
7.
A. G. M. Steerneman E. A. van der Meulen W. Schaafsma G. N. van Vark 《Human Evolution》1990,5(5):449-456
Research on human evolution and sexual dimorphism motivates an interesting test problem. In studying hominid phylogeny it
is of interest to test whether parallel evolution plays a role. With regard to sexual dimorphism it is of interest to known
whether the directions of sexual dimorphism in the populations being compared are the same. We show that testing these two
problems gives rise to the same type of hypothesis testing, viz. the problem of testing the hypothesis that the means of independent,
normally distributed random vectors with unit covariance matrices are situated on a straight line through the origin. A test
is proposed and applied to study the sexual dimorphism of 20 recent skull populations. In this example the hypothesis of equal
directions of sexual dimorphism is rejected. The classical theory of constructing multiple discriminant functions (canonical
variates) is adapted to the problem of comparing sexual dimorphisms. 相似文献
8.
A simple procedure is described for the determination of the photosensitizing potency of drugs, using three leukemic cell lines, two of lymphocytic origin, L1210 and P388 and one of erythroid type, Friend-745. The procedure allows one to investigate several aspects of the photosensitization properties of tested compounds such as cellular localization and direct (trypan blue exclusion) or delayed (clonogenicity) photomediated toxicities.The method was assessed using crude hematoporphyrin derivative (HPD) as well as dihematoporphyrin ether (DHE) or commercially available Photofrin II. Results were compared to those obtained with normal cells, e.g spleen lymphocytes and erythropoietic stem cells (CFU-e), and discussed in the light of the relative response of normal versus transformed cells.Abbreviations DHE
Dihematoporphyrin Ether
- FCS
Fetal Calf Serum
- HPD
Hematoporphyrin Derivative
- PDT
Photodynamic Therapy 相似文献
9.
10.
Results from three experiments on basic learning and transfer in rhesus monkeys (Macaca mulatta) are reported in which fully automated testing paradigms, afforded by the Language Research Center's Computerized Test System
(LRC-CTS), were employed. Performance levels for discrimination learning set, transfer index, and mediational-learning testing
were uniformly higher than was predicted from the literature, in contrast to previous reports of compromised learning under
similar conditions (automated apparatus, planimetric stimuli, spatial discontiguity between stimuli and response loci). Analyses
reveal relatively advanced learning set performance, transfer-index ratios, and positive transfer of learning even at stringent
criterion levels. Moreover, the data suggest that rhesus monkeys tested in these experiments exhibit mediational instead of
associative learning strategies, as do great apes and in contrast to previous reports of rhesus learning. We argue that the
LRC-CTS enhances learning by nonhuman primate subjects, obviating those factors, reported in the literature from experiments
in which manual or other automated systems were employed, that compromise learning. 相似文献