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Schroten-Loef C de Ridder CM Reneman S Crezee M Dalgleish A Todryk SM Bangma CH Kraaij R 《Cancer immunology, immunotherapy : CII》2009,58(3):373-381
A panel of cytokine-secreting RM-9 prostate cancer cells were tested as whole cell vaccines to determine their capacity to
evoke an anti-prostate cancer immune response. In our model, vaccines secreting mGM-CSF or mIL-7 resulted in the highest increase
in circulating T lymphocytes after vaccination, prolonged survival and, in a proportion of animals, tumor-free survival. Anti-tumor
effects were more evident after a subcutaneous RM-9 challenge than after an intraprostatic challenge. However, when the RM-9/mGM-CSF
cell line was used as intraprostatic tumor challenge, protection after RM-9/mIL-7 vaccination was restored. 相似文献
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