实验动物许可证管理现状分析

随着生命科学研究的发展,我国实验动物科学进入快速发展时期,加强实验动物行业的规范化管理彰显重要。实验动物许可证管理是实验动物工作规范化、科学化管理的重要组成部分,同时也是推进实验动物学科发展的重要途径。随着国家实验动物立法和各省市对实验动物的配套立法等工作,促进了实验动物行业的有序发展,加强实验动物许可证的有效管理,对于促进我国实验动物的产业化和规范国家实验动物管理发挥了重要的推动与保障作用。本文对我国实验动物许可证管理现状进行分析,以对实验动物管理工作提供参考。     

Restauro-G： A Rapid Genome Re-Annotation System for Comparative Genomics

of complete genome sequences submitted directly from sequencing projects are diverse in terms of annotation strategies and update frequencies. These inconsistencies make comparative studies difficult. To allow rapid data preparation of a large number of complete genomes, automation and speed are important for genome re-annotation. Here we introduce an open-source rapid genome re-annotation software system, Restauro-G, specialized for bacterial genomes. Restauro-G re-annotates a genome by similarity searches utilizing the BLASTLike Alignment Tool, referring to protein databases such as UniProt KB, NCBI nr, NCBI COGs, Pfam, and PSORTb. Re-annotation by Restauro-G achieved over 98% accuracy for most bacterial chromosomes in comparison with the original manually curated annotation of EMBL releases. Restauro-G was developed in the generic bioinformatics workbench G-language Genome Analysis Environment and is distributed at http：//restauro-g.iab.keio.ac.jp/ under the GNU General Public License.