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Two new eudesmanolide type sesquiterpenes, indicusalactone (1) and ()-oxyfrullanolide (2), along with twelve known compounds (314), were isolated from the aerial parts of Sphaeranthus indicus. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Compounds 14 and 1214 showed antimalarial activity against Plasmodium falciparum with IC50 values ranging from 2.32 to 6.47μg/mL. In addition, compounds 25 showed cytotoxicity against cancer cell lines, KB, NCI-H187 and MCF-7 with IC50 values within the range 1.2346.19 μg/mL. 相似文献
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