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Kimura K 《Development, growth & differentiation》2011,53(2):236-244
Currently, sex differences in behavior are believed to result from sexually dimorphic neural circuits in the central nervous system (CNS). Drosophila melanogaster is a common model organism for studying the relationship between brain structure, behavior, and genes. Recent studies of sex‐specific reproductive behaviors in D. melanogaster have addressed the contribution of sexual differences in the CNS to the control of sex‐specific behaviors and the development of sexual dimorphism. For example, sexually dimorphic regions of the CNS are involved in the initiation of male courtship behavior, the generation of the courtship song, and the induction of male‐specific muscles in D. melanogaster. In this review, I discuss recent findings about the contribution of cell death to the formation of sexually dimorphic neural circuitry and the regulation of sex‐specific cell death by two sex determination factors, Fruitless and Doublesex, in Drosophila. 相似文献
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Over the past 35 years, developmental geneticists have made impressive progress
toward an understanding of how genes specify morphology and function, particularly as
they relate to the specification of each physical component of an organism. In the
last 20 years, male courtship behavior in Drosophila melanogaster
has emerged as a robust model system for the study of genetic specification of
behavior. Courtship behavior is both complex and innate, and a single gene,
fruitless (fru), is both necessary and sufficient for all aspects of the
courtship ritual. Typically, loss of male-specific Fruitless protein function results
in male flies that perform the courtship ritual incorrectly, slowly, or not at all.
Here we describe a novel requirement for fru: we have identified a group of cells in which male Fru
proteins are required to reduce the speed of courtship initiation. In addition, we
have identified a gene, Trapped in endoderm
1 (Tre1), which is required in these cells for normal courtship
and mating behavior. Tre1 encodes a G-protein-coupled receptor required for
establishment of cell polarity and cell migration and has previously not been shown
to be involved in courtship behavior. We describe the results of feminization of the
Tre1-expressing neurons, as well as the effects on courtship
behavior of mutation of Tre1. In addition, we show that Tre1 is expressed in a sexually dimorphic pattern in the
central and peripheral nervous systems and investigate the role of the
Tre1 cells in mate identification. 相似文献
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《Current biology : CB》2019,29(22):3887-3898.e4
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