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Anastasios Malandrakis Efrosini Rafaella Daskalaki Vasiliki Skiada Kalliope K. Papadopoulou Nektarios Kavroulakis 《Fungal biology》2018,122(12):1215-1221
The potential of FsK, a non-pathogenic endophytic Fusarium solani strain, to be utilized as a biocontrol agent in combination with nine selected fungicides registered in tomato crops in Greece was evaluated. In vitro fungitoxicity tests revealed that FsK was insensitive to doses exceeding 100 μg/mL of thiophanate-methyl, fenhexamid, cyprodinil, boscalid and mancozeb. On the contrary, prochloraz, fludioxonil, pyraclostrobin and difenoconazole were most toxic to FsK. None of the later fungicides affected conidial production in an adverse way. Drenching of tomato plants with the above fungicides at recommended doses did not significantly affect colonization of tomato roots by FsK as revealed by in vitro isolation and Real Time PCR quantification. The disease suppressive ability of FsK against Fusarium oxysporum f.sp.radicis lycopersici (FORL) was not adversely affected by the post-inoculation application of commercial formulations of fludioxonil (Switch) and pyraclostrobin (Comet) at the recommended doses. Even more, the Comet–FsK combination resulted in enhanced disease suppression compared to either of the two treatments applied individually. In conclusion, not only biocontrol agent FsK is suitable for use in tomato integrated disease management programs that include all tested fungicides but also, some FsK –fungicide combinations can have additive effect against FORL disease incidence. 相似文献
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Ziad Ramadan Peifang Zhang Doris M. Jacobs Isabelle Tavazzi Sunil Kochhar 《Metabolomics : Official journal of the Metabolomic Society》2007,3(2):113-119
The feline odontoclastic resorptive lesion (FORL) is a common oral problem in cats. The disease has increased steadily since
the domestication of cats and etiology of this disease has not been fully determined although several theories have been proposed.
Feeding practices, vaccination, and neutering programs have all been suspected to be associated with FORL. The aim of the
current study is to assess the feasibility of metabonomics to detect at an early stage the onset of the disease. The diagnostic
biomarkers could then be used as “efficacy markers” for nutritional intervention in preventing and/or slowing the progression
of FORL. 1H-NMR- and LC/MS-based metabonomic analysis of saliva samples obtained from a group of 21 cats (11 healthy and 10 FORL diseased)
showed clear differences in the metabolic composition of saliva from healthy and FORL-diseased cats. To identify biomarkers,
the spectroscopic data was processed using partial least-squares discriminant analysis (PLS-DA) and validated by leave-one-subject-out
cross validation. The PLS-DA model predicted FORL- diseased cats with over 60% accuracy. The maximum value of Q2 of the random permutation sets was less than 0.3. The diseased cats showed increased levels of many organic and amino acids,
such as acetate, lactate, propionate, isovalerate, tryptamine, and phenylalanine suggesting changes in oral microflora in
the disease situation. This study is preliminary and a larger study with more samples to further validate the biomarker profile
predictive of an early FORL pathophysiological status is in progress. 相似文献
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