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Rates of peptide bond hydrolysis by cobalt(III) complexes: observation by rate of amino acid release
The rates of hydrolysis of eleven dipeptides (Gly-Gly; Gly-l-Leu; Gly-d,l-Val; Gly-l-Phe: d,l-Leu-Gly; l-Leu-l-Tyr; l-Pro-l-Tyr; l-Ala-l-Phe; l-Val-Gly; l-Val-l-Ile; l-Ile-l-Val) by cis-β-Co(trien)(OH)(H2O)2+ under pseudo first order conditions (excess Co(III)) are reported. The rates are determined by the rate of amino acid release by liquid chromatography. The range of rates observed for the eleven dipeptides is 10.1. Two of the dipeptides are hydrolyzed more rapidly than Gly-Gly, the remaining six more slowly. Phosphate does not have any significant effect on the rate of peptide hydrolysis. Aquohydroxy-1,8-diamino-3,6-dithiaoctanecobalt(III)2+ did not hydrolyze Gly-Gly at 25°, pH8, and aquohydroxy-1,6-bis-(α-pyridyl)-2,5-diazahexanecobalt(III)2+ did not hydrolyze Gly-Gly at 65°, pH 8, to any significant extent. 相似文献
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The antifungal antibiotics Sinefungin and A9145C isolated from Streptomyces griseolus and the synthetic nucleoside Siba, which are analogs of S-adenosylmethionine, inhibit the activity of 1-aminocyclopropane 1-carboxylic acid synthase from tomato fruits. Sinefungin and Siba were shown to be more potent inhibitors than A9145C. In extracts of green fruits, the enzyme activity was inhibited by Sinefungin with an I50 of 1 microM, which was similar to that caused by aminoethoxyvinylglycine, and by Siba with an I50 of 100 microM; in extracts from red tomatoes, the I50's were 25 microM and 100 microM, respectively. The inhibition of ACC synthase by these analogs could be reversed by gel filtration chromatography. 相似文献
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