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A novel dodecadepsipeptide, cereulide, isolated from Bacillus cereus causes vacuole formation in HEp-2 cells 总被引:1,自引:0,他引:1
Norio Agata Masashi Mori Michio Ohta Sathorn Suwan Ikuko Ohtani Minoru Isobe 《FEMS microbiology letters》1994,121(1):31-34
Abstract A HEp-2 cell-vacuolation factor was extracted and purified from the culture supernatant of a Bacillus cereus strain which caused emetic-syndrome food poisoning. The final preparation was chemically pure, and the toxin was named as cereulide. Mass spectrometry, NMR studies and chemical degradation revealed that the cereulide is a cyclic dodecadepsipeptide, (D-O-Leu-D-Ala- L-O-Val-L-Val)3 , which is closely related to the potassium ionophore, valinomycin. 相似文献
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