全文获取类型
收费全文 | 5279篇 |
免费 | 369篇 |
国内免费 | 148篇 |
专业分类
5796篇 |
出版年
2024年 | 13篇 |
2023年 | 125篇 |
2022年 | 185篇 |
2021年 | 263篇 |
2020年 | 167篇 |
2019年 | 198篇 |
2018年 | 161篇 |
2017年 | 113篇 |
2016年 | 130篇 |
2015年 | 163篇 |
2014年 | 294篇 |
2013年 | 283篇 |
2012年 | 192篇 |
2011年 | 199篇 |
2010年 | 141篇 |
2009年 | 196篇 |
2008年 | 262篇 |
2007年 | 220篇 |
2006年 | 209篇 |
2005年 | 157篇 |
2004年 | 165篇 |
2003年 | 143篇 |
2002年 | 124篇 |
2001年 | 114篇 |
2000年 | 120篇 |
1999年 | 127篇 |
1998年 | 96篇 |
1997年 | 116篇 |
1996年 | 103篇 |
1995年 | 109篇 |
1994年 | 97篇 |
1993年 | 107篇 |
1992年 | 80篇 |
1991年 | 53篇 |
1990年 | 63篇 |
1989年 | 70篇 |
1988年 | 45篇 |
1987年 | 44篇 |
1986年 | 44篇 |
1985年 | 41篇 |
1984年 | 44篇 |
1983年 | 29篇 |
1982年 | 36篇 |
1981年 | 35篇 |
1980年 | 22篇 |
1979年 | 14篇 |
1977年 | 12篇 |
1976年 | 13篇 |
1972年 | 12篇 |
1970年 | 11篇 |
排序方式: 共有5796条查询结果,搜索用时 8 毫秒
1.
《Cell reports》2020,30(1):164-172.e4
- Download : Download high-res image (143KB)
- Download : Download full-size image
2.
Elizabeth Storer Scholl Antonella Pirone Daniel H Cox R Keith Duncan Michele H Jacob 《Channels (Austin, Tex.)》2014,8(1):62-75
Small conductance Ca2+-sensitive potassium (SK2) channels are voltage-independent, Ca2+-activated ion channels that conduct potassium cations and thereby modulate the intrinsic excitability and synaptic transmission of neurons and sensory hair cells. In the cochlea, SK2 channels are functionally coupled to the highly Ca2+ permeant α9/10-nicotinic acetylcholine receptors (nAChRs) at olivocochlear postsynaptic sites. SK2 activation leads to outer hair cell hyperpolarization and frequency-selective suppression of afferent sound transmission. These inhibitory responses are essential for normal regulation of sound sensitivity, frequency selectivity, and suppression of background noise. However, little is known about the molecular interactions of these key functional channels. Here we show that SK2 channels co-precipitate with α9/10-nAChRs and with the actin-binding protein α-actinin-1. SK2 alternative splicing, resulting in a 3 amino acid insertion in the intracellular 3′ terminus, modulates these interactions. Further, relative abundance of the SK2 splice variants changes during developmental stages of synapse maturation in both the avian cochlea and the mammalian forebrain. Using heterologous cell expression to separately study the 2 distinct isoforms, we show that the variants differ in protein interactions and surface expression levels, and that Ca2+ and Ca2+-bound calmodulin differentially regulate their protein interactions. Our findings suggest that the SK2 isoforms may be distinctly modulated by activity-induced Ca2+ influx. Alternative splicing of SK2 may serve as a novel mechanism to differentially regulate the maturation and function of olivocochlear and neuronal synapses. 相似文献
3.
4.
P. Gerrans 《Biology & philosophy》2007,22(1):35-56
Delusions are currently characterised as false beliefs produced by incorrect inference about external reality (DSM IV). This
inferential conception has proved hard to link to explanations pitched at the level of neurobiology and neuroanatomy. This
paper provides that link via a neurocomputational theory, based on evolutionary considerations, of the role of the prefrontal
cortex in regulating offline cognition. When pathologically neuromodulated the prefrontal cortex produces hypersalient experiences
which monopolise offline cognition. The result is characteristic psychotic experiences and patterns of thought. This bottom-up
account uses neural network theory to integrate recent theories of the role of dopamine in delusion with the insights of inferential
accounts. It also provides a general model for evolutionary psychiatry which avoids theoretical problems imported from evolutionary
psychology. 相似文献
5.
《Neuron》2020,105(6):1062-1076.e6
6.
Summary . We propose a fully inferential model-based approach to the problem of comparing the firing patterns of a neuron recorded under two distinct experimental conditions. The methodology is based on nonhomogeneous Poisson process models for the firing times of each condition with flexible nonparametric mixture prior models for the corresponding intensity functions. We demonstrate posterior inferences from a global analysis, which may be used to compare the two conditions over the entire experimental time window, as well as from a pointwise analysis at selected time points to detect local deviations of firing patterns from one condition to another. We apply our method on two neurons recorded from the primary motor cortex area of a monkey's brain while performing a sequence of reaching tasks. 相似文献
7.
8.
Upregulation of small heat-shock proteins (sHsps) in response to cellular stress is one mechanism to increase cell viability. We previously described that cultured rat hippocampal neurons express five of the 11 family members but only upregulate two of them (HspB1 and HspB5) at the protein level after heat stress. Since neurons have to cope with many other pathological conditions, we investigated in this study the expression of all five expressed sHsps on mRNA and protein level after sublethal sodium arsenite and oxidative and hyperosmotic stress. Under all three conditions, HspB1, HspB5, HspB6, and HspB8 but not HspB11 were consistently upregulated but showed differences in the time course of upregulation. The increase of sHsps always occurred earlier on mRNA level compared with protein levels. We conclude from our data that these four upregulated sHsps (HspB1, HspB5, HspB6, HspB8) act together in different proportions in the protection of neurons from various stress conditions. 相似文献
9.
10.