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Wang XJ Xu HW Guo LL Zheng JX Xu B Guo X Zheng CX Liu HM 《Bioorganic & medicinal chemistry letters》2011,21(10):3074-3077
Three series of butenolide-containing dithiocarbamates were designed and synthesized. Their anti-tumor activity in vitro was evaluated. Among them compound I-14 exhibited broad spectrum anti-cancer activity against five human cancer cell lines with IC50 <30 μM. Structure-activity relationship analysis showed that the introduction of dithiocarbamate side chains on the C-3 position of butenolide was crucial for anti-tumor activity. 相似文献
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Changxing Qi Weixi Gao Danyingzi Guan Jianping Wang Mengting Liu Chunmei Chen Hucheng Zhu Yuan Zhou Yongji Lai Zhengxi Hu Qun Zhou Yonghui Zhang 《Bioorganic & medicinal chemistry》2018,26(22):5903-5910
Chemical study on the extract of a marine-derived fungus Aspergillus terreus yielded twelve butenolide derivatives, including three new compounds, namely asperlides A–C (1–3) and nine known butenolides (4–12). The structures of 1–3 were confirmed by comprehensive spectroscopic analysis, including HRESIMS, NMR spectroscopy, and calculated electronic circular dichroism (ECD). The cytotoxicity of the compounds was evaluated using PANC-1, HCC1806, HepG2, BEAS-2B and HT-29 cancer cells. The results showed that (+)-3′,3′-di-(dimethylallyl)-butyrolactone II (4) and versicolactone B (6) exhibited the most potent cytotoxin of PANC-1 cell line, with the IC50 values of 5.3 and 9.4?μM, respectively. Morphological features of apoptosis were observed in 4 and 6-treated PANC-1 cells, including apoptotic body formation, membrane blebbing, cell shrinkage and nuclear condensation. Cell cycle analysis with propidium iodide staining exhibited that 4 inhibits proliferation of PANC-1 cells via the induction of G2/M and S phase arrest, while 6 could retard the PANC-1 cells via the induction of S phase arrest. Flow cytometric analysis suggested that treatment with 4 and 6 significantly induced PANC-1 cells apoptosis. These findings indicated that 4 and 6 might serve as a starting point for the development of an anticancer drug for the treatment of pancreatic ductal adenocarcinoma. 相似文献
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Rajesh R. Parvatkar Celina D’Souza Ashootosh Tripathi Chandrakant G. Naik 《Phytochemistry》2009,70(1):128-1452
Two aromatic butenolides, aspernolides A and B along with the known metabolites, butyrolactone I, terrein and physcion were isolated from the fermentation broth of a soft coral derived fungus Aspergillus terreus. The structures of these metabolites were assigned on the basis of detailed spectroscopic analysis. The absolute stereochemistry of aspernolides A (1) and B (2) was established by their preparation from the known butyrolactone I. Biogenetically aspernolides A and B must be derived from butyrolactone I, a well known specific inhibitor of cyclin dependent kinase (cdk) from A. terreus. When tested, aspernolide A exhibited mild cytotoxicity against cancer cell lines. 相似文献
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Prem P. Yadav Ranjani Maurya Ashish Arora Sudhir Sinha Ram Raghubir 《Phytochemistry》2009,70(2):256-261
Three cassane diterpene hemiketals, caesalpinolide-C, caesalpinolide-D, caesalpinolide-E and one cassane furanoditerpene were isolated from Caesalpinia bonduc. The molecular structures were elucidated using NMR spectroscopy in combination with IR, UV and mass spectral data and relative stereochemistries were determined through ROESY correlation. The isolated compounds were tested for their antiproliferative activity against MCF-7 (breast adenocarcinoma), DU145 (prostate carcinoma), C33A (Cervical carcinoma) and Vero (African green monkey kidney fibroblast) cells. 相似文献
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Tang Wang Yi Jiang Kai‐Xia Ma Yi‐Qing Li Rong Huang Xiao‐Song Xie Shao‐Hua Wu 《化学与生物多样性》2014,11(6):929-933
Two new butenolides, (4S)‐4,10‐dihydroxydodec‐2‐en‐1,4‐olide ( 1 ) and (4S)‐4,8,10‐trihydroxy‐10‐methyldodec‐2‐en‐1,4‐olide ( 2 ), together with three known compounds, MKN‐003B ( 3 ), MKN‐003C ( 4 ), and cyclo(Ala‐Leu) ( 5 ), were isolated from the culture broth of a bacterium of the genus Streptomyces derived from soil environment. The structures of these compounds were elucidated on the basis of spectroscopic analysis. The inhibitory activities of the butenolides against eight pathogenic fungi were evaluated. All of the butenolides showed moderate‐or‐weak antifungal activities in a broth microdilution assay. 相似文献
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