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Muangsombut V Suparak S Pumirat P Damnin S Vattanaviboon P Thongboonkerd V Korbsrisate S 《Archives of microbiology》2008,190(6):623-631
Burkholderia pseudomallei, an infectious Gram-negative bacterium, is the causative pathogen of melioidosis. In the present study, a B.
pseudomallei strain with mutation in the bsaQ gene, encoding a structural component of the type III secretion system (T3SS), was constructed. This bsaQ mutation caused a marked decrease in secretion of BopE effector and BipD translocator proteins into culture supernatant.
The B.
pseudomallei
bsaQ mutant also exhibited decreased efficiencies of plaque formation, invasion into non-phagocytic cells and multinucleated giant
cell (MNGC) development in a J774A.1 macrophage cell line. Co-localization of the bacteria and lysosome-associated membrane
glycoprotein-1 (LAMP-1) containing vesicles suggested that defects in MNGC formation may result from the delayed ability of
this B.
pseudomallei mutant to escape from the vacuoles of macrophages.
Veerachat Muangsombut and Supaporn Suparak contributed equally to this work. 相似文献
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