Biflavonoids from Lonicera japonica

Two biflavonoids, 3'-O-methyl loniflavone [5,5',7,7'-tetrahydroxy 3'-methoxy 4',4'-biflavonyl ether (1)] and loniflavone [5,5',7,7',3'-pentahydroxy 4',4'-biflavonyl ether (2)] along with luteolin (3) and chrysin (4) were isolated from the leaves of Lonicera japonica. The structures were established on the basis of UV/vis, 1D, 2D NMR (HMQC and HMBC) and ESI-QTOF-MS/MS spectroscopic methods and chemical evidences.     

深绿卷柏的一个新双黄酮

从云南产中药深绿卷柏 (Selaginelladoederleinii)中分离得到一个新的双黄酮类化合物 ,通过波谱分析和文献数据比较 ,确定其结构为具有 3′～ 6″连接的 4′ -甲氧基罗伯斯特黄酮。     

Three new compounds from the roots of Juglans mandshurica Maxim.

A new biflavone glycoside juglbiflavone A (1) along with two new lupane-type triterpenes (2-3) were identified from the roots of Juglans mandshurica Maxim. Their structures and absolute configurations were elucidated by extensive spectroscopic methods including 1D/2D NMR, HRESIMS and CD. Compound 1 is the first example of biflavone glycoside consisted of a flavanol unit and a flavone unit from this genus, which also exhibited moderate cytotoxic activity against SGC-7901 and A549 cell lines in vitro with IC₅₀ values of 10.08 ± 0.52 μM and 12.44 ± 1.21 μM, respectively.