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Atsushi Satoh Yasushi Nagatomi Yukari Hirata Satoru Ito Gentaroh Suzuki Toshifumi Kimura Shunsuke Maehara Hirohiko Hikichi Akio Satow Mikiko Hata Hisashi Ohta Hiroshi Kawamoto 《Bioorganic & medicinal chemistry letters》2009,19(18):5464-5468
We identified 4-fluoro-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methylbenzamide 27 as a potent mGluR1 antagonist. The compound possessed excellent subtype selectivity and good PK profile in rats. It also demonstrated relatively potent antipsychotic-like effects in several animal models. Suitable for development as a PET tracer, compound 27 would have great potential for elucidation of mGluR1 functions in human. 相似文献
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