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两株不同来源的蓖麻蚕核型多角体病毒(ArscsNPV和ArNPV)经提纯后,使用SDS—苯酚抽提病毒核酸,并使用限制性内切酶EcoRI,BamHI酶解后,用分子杂交方法与缺口平移标记的ArscsNPV-DNA探针杂交,分析了两株蓖麻蚕NPV病毒核酸的同源性。EcoRI酶解的ArNPV-DNA产生8个片段,其中5个片段能与ArscsNPV-DNA探针杂交。BamHI酶解ArNPV-DNA产生7个片段,其中6个片段能与ArscsNPV-DNA探针杂交。结果表明:两株蓖麻蚕NPV之间病毒核酸具有很高的同源性。使用斑点杂交方法分析了ArscsNPV与ArNPV,柞蚕NPV及家蚕NPV之间的核酸同源性,结果表明:ArscsNPV与ArNPV,柞蚕NPV具有同源性。而与家蚕NPV无核酸同源性。 相似文献
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In the present contribution, we performed ab initio Møller-Plesset perturbation theory second-order (MP2) calculations in the framework of the supermolecule approach on the vertical excitation spectra of the weakly bound van der Waals CO-Ar molecule in its "near T-shaped" most stable ground state structure, as a guideline for future theoretical and experimental work. These test calculations indicate a ground CO ( X 1 D )- Ar ( 1 S ) interaction with R e =3.72 Å, D e =109 cm -1 and D o =92 cm -1 . They also indicate an excited CO ( A 1 @ )- Ar ( 1 S ) interaction with R e =3.55 Å, D e =141 cm -1 and D o =121 cm -1 . A red shift of 29 cm -1 for the CO ( X 1 D )- Ar ( 1 S ) M CO ( A 1 @ )- Ar ( 1 S ) vertical excitation energy, with respect to the corresponding CO ( X 1 D ) M CO ( A 1 @ ) excitation in the absence of Ar, can be obtained by comparing the corresponding D o values. 相似文献
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Trauth MH Maslin MA Deino AL Strecker MR Bergner AG Dühnforth M 《Journal of human evolution》2007,53(5):475-486
The late Cenozoic climate of East Africa is punctuated by episodes of short, alternating periods of extreme wetness and aridity, superimposed on a regime of subdued moisture availability exhibiting a long-term drying trend. These periods of extreme climate variability appear to correlate with maxima in the 400-thousand-year (kyr) component of the Earth's eccentricity cycle. Prior to 2.7 Ma the wet phases appear every 400 kyrs, whereas after 2.7 Ma, the wet phases appear every 800 kyrs, with periods of precessional-forced extreme climate variability at 2.7-2.5 Ma, 1.9-1.7 Ma, and 1.1-0.9 Ma before present. The last three major lake phases occur at the times of major global climatic transitions, such as the onset of Northern Hemisphere Glaciation (2.7-2.5 Ma), intensification of the Walker Circulation (1.9-1.7 Ma), and the Mid-Pleistocene Revolution (1.0-0.7 Ma). High-latitude forcing is required to compress the Intertropical Convergence Zone so that East Africa becomes locally sensitive to precessional forcing, resulting in rapid shifts from wet to dry conditions. These periods of extreme climate variability may have provided a catalyst for evolutionary change and driven key speciation and dispersal events amongst mammals and hominins in East Africa. 相似文献
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Hajipour AR Guo LW Pal A Mavlyutov T Ruoho AE 《Bioorganic & medicinal chemistry》2011,19(24):7435-7440
The sigma-2 (σ2) receptor has been suggested to be a promising target for pharmacological interventions to curb tumor progression. Development of σ2-specific ligands, however, has been hindered by lack of understanding of molecular determinants that underlie selective ligand-σ2 interactions. Here we have explored effects of electron donating and withdrawing groups on ligand selectivity for the σ2 versus σ1 receptor using new benzamide-isoquinoline derivatives. The electron-donating methoxy group increased but the electron-withdrawing nitro group decreased σ2 affinity. In particular, an extra methoxy added to the para-position (5e) of the benzamide phenyl ring of 5f dramatically improved (631 fold) the σ2 selectivity relative to the σ1 receptor. This para-position provided a sensitive site for effective manipulation of the sigma receptor subtype selectivity using either the methoxy or nitro substituent. Our study provides a useful guide for further improving the σ2-over-σ1 selectivity of new ligands. 相似文献
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不同离子辐照对离体质粒DNA损伤与转化活性的影响 总被引:3,自引:0,他引:3
利用 30Kev的N+ 、Ar+ 离子辐照离体质粒DNA ,分析了不同离子对DNA单双链断裂及转化活性的影响。结果表明 :N+ 、Ar+ 离子辐照均可引起质粒DNA单双链断裂和转化活性的变化 ,且随着辐照剂量的增加 ,单双链断裂频率增加 ,转化活性下降。Ar+对离体质粒DNA比N+ 具有更强的单双链断裂效应 ,且从 9× 10 15Ar+ cm2 剂量开始 ,质粒可完全丧失转化活性。质粒转化活性的大小与DNA单双链断裂频率呈正相关 相似文献
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Efficient Solar‐Driven Water Oxidation over Perovskite‐Type BaNbO2N Photoanodes Absorbing Visible Light up to 740 nm
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Takashi Hisatomi Mamiko Nakabayashi Naoya Shibata Tsutomu Minegishi Masao Katayama Kazunari Domen 《Liver Transplantation》2018,8(24)
Photoelectrochemical water splitting using semiconductors absorbing a wide range of visible light is a potentially attractive means of harvesting large portions of the solar spectrum. However, this is also very challenging because narrowing the semiconductor band gap lowers the driving force for photoreactions. Herein, a highly active perovskite BaNbO2N exhibiting photoexcitation up to 740 nm for water oxidation is reported. The synthesis route, consisting of moderate nitridation and subsequent annealing in inert Ar flow, enhances the crystallinity of the BaNbO2N surface without inducing the reduction of the Nb species. As a result, a particulate BaNbO2N photoanode exhibits a photocurrent of 5.2 mA cm?2 at 1.23 VRHE under simulated solar irradiation, which is the highest yet reported for an oxynitride responsive at wavelengths above 600 nm. Suppressing the reduction of B‐site cations during the synthesis of perovskite AB(O,N)3, which otherwise results in surface defects or impurities, is critical for achieving high water oxidation activity. 相似文献
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Andrea M. Stancin James D. Gleason Steven A. Hovan David K. Rea Robert M. Owen Theodore C. Moore Jr. Chris M. Hall Joel D. Blum 《Palaeogeography, Palaeoclimatology, Palaeoecology》2008,261(3-4):218-233
A 14-meter long pelagic clay core recovered at Marlin Rise (40°00.531′S, 154°2.601′W; 4775 m water depth) in the Southwest Pacific Basin contains a record of eolian dust deposited since the early Miocene. Downcore analysis of detrital minerals reveals a dominantly eolian signature with relatively constant proportions of quartz, feldspar and illite and trace amounts of chlorite, kaolinite and smectite, consistent with a continental (loess-like) source region. Fish tooth Sr isotope stratigraphy reveals the base of the core to be 17.5 Ma, with low sedimentation rates (< 0.5 mm/kyr LSR) indicated for the interval 17.5 to 10 Ma; several hiatuses in deposition appear to be present upcore, but are beyond the age resolution of the fish teeth stratigraphy. These intervals are revealed as apparent discontinuities in the Sr isotope record, accompanied by pulses of anomalously rapid sedimentation at ~ 10 Ma, 6.7 Ma and 4.1 Ma. Bulk mass accumulation rates (MAR) are calculated at ~ 10 mg/cm2/kyr over the last 4 Myr, consistent with previously estimated Quaternary eolian flux rates to this part of the Pacific. Nd, Pb and Sr radiogenic isotopic compositions of the detrital mineral extract (< 38 µm) show no trends with age, while 40Ar/39Ar ages show an upcore younging trend (~180 Ma to ~150 Ma), in concert with a slight coarsening of eolian grain-size distributions. These ages likely reflect mixing of Mesozoic illite-dominated clay from at least two continental source areas: southeastern Australia (Murray–Darling Basin/Lake Eyre Basin) and New Zealand (South Island). The data indicate remarkable constancy of continental eolian sources exposed to weathering and dispersal at this latitude during the Neogene. 相似文献
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V. V. Litvak I. Ya. Mainagashev O. G. Bukhanets 《Nucleosides, nucleotides & nucleic acids》2013,32(9):1373-1385
Interaction of pentafluoropyridine with hydroxyl groups of thymidine, uridine, adenosine, and deoxyadenosine at room temperature leads to the formation of aryl ethers of nucleosides with a high yield. Under severe conditions, one more tetrafluoropyridine residue is attached to pyrimidine fragments of T and U, while purine heterocycle in A remains intact. Nucleoside derivatives are formed with a quantitative yield and can be used in situ as intermediates for, as an example, molecular design of arene analogs of nucleic acids. The reaction with thymidine is a successive-parallel process, the limited stage being arylation of the secondary hydroxyl group. The presence of the vicinal hydroxyl group in pentose results in the opposite rate ratio of the formation of primary and secondary tetrafluoropyridyl ethers of adenine and uridine. 相似文献