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Ohmefentanyl stereoisomers induce changes of CREB phosphorylation in hippocampus of mice in conditioned place preference paradigm 总被引:4,自引:0,他引:4
The present study was designed to determine the changes of phosphorylation of cAMP-response element binding protein(CREB)in hippocampus induced by ohmefentanyl stereoisomers(F9202 and F9204) in conditioned place preference(CPP)paradigm.The results showed that mice receiving F9202 and F9204 displayed obvious CPP.They could all significantly stimulate CREB phosphorylation and maintained for a long time without affecting total CREB protein levels.The effect of F9204 was similar to morphine which effect was more potent and longer than F9202.We also examined the effects of ketamine,a noncompetitive N-mthyl-D-asartate receptor(NR)antagonist,on morphine-,F9202-and F9204-induced CPP and phosphorylation of CREB in hippocampus.Ketamine could suppress not only the place preference but also the phosphorylation of CREB produced by morphine,F9202 and F9204.These findings suggest that alterations in the phosphorylation of CREB be relevant to opiates signaling and the development of opiates dependence.NR antagonists may interfere with opiates dependence and may have potential therapeutic implications. 相似文献
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目的:研究一种对家兔血压影响小于常用麻醉剂,适用于家兔动脉血压实验的一种全身麻醉复合剂.方法:将氯胺酮、乌拉坦、戊巴比妥钠和水合氯醛有序分组,按不同比例配置麻醉复合剂对家兔进行耳缘静脉注射,观察记录并比较给药前后动脉血压的变化、麻醉维持时间、痛觉、角膜反射、肌张力、呼吸、心率变化.结果:①氯胺酮、水合氯醛、乌拉坦和戊巴比妥钠四种药物联合给药时家兔颈总动脉血压122± 3mmHg,波动范围在开口时血压的5mmHg内,是整个实验过程中血压波动最小的,对动脉血压的影响小于常用麻醉剂25%乌拉坦(10mmHg左右).②麻醉后生理状态平稳,角膜反射消失,肌张力明显减弱,呼吸频率减慢,骨痛反应消失,麻醉持续时间大于90min,降低了每种药物的用药量从而增加了麻醉药物的安全性.结论:1.35%氯胺酮(0.4mL/kg)、25%乌拉坦( 0.8mL/kg)、5%水合氯醛(0.3mL/kg)和3%戊巴比妥钠(0.2mL/kg)复合给药时对家兔血压影响最小、麻醉维持时间长、麻醉效果理想,是一种适合于家兔血压实验的复合麻醉剂. 相似文献
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《现代生物医学进展》2012,(16):3162
兹有我刊2011年12月第23-Ⅰ期杂志第4645页刊登的文章《动物血压实验麻醉剂的选用与比较》有误。应改为"李若苗,李国良,邓金霞,彭秀峰,罗怀青△",第一作者:李若苗,女,本科学生,E-mail:459571930@qq.com;△通讯作 相似文献
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七氟烷作为一种吸入麻醉剂已广泛用于临床。通过国内外研究综述,结合现有生产能力、产销状况,说明七氟烷是一种非常优良的新型吸入麻醉剂。 相似文献
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第30届国际麻醉剂研究学术会议于1999年7月10~15日在美国纽约SaratogaSprings召开。到会学者有美、瑞典、法、日、德、英等17个国家地区代表计272人。其中中国大陆学者仅2人,美国学者达190人,但其中不少为我国留学人员或华人科学家有29人之多,占15%。如包... 相似文献
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本实验以丁香酚和日本沼虾为对象,研究了丁香酚对日本沼虾因温度的急剧变化和形态测量所造成的应激反应的抑制效果.结果显示,丁香酚浓度为500 mg/L时,对照组和实验组的存活率开始呈显著下降趋势的温差幅度分别为10和14℃;当温差为18℃时,对照组存活率为0,实验组存活率为0.653±0.033;当温差达到10℃后,实验组存活率明显高于对照组存活率(P<0.05).形态测量结果显示,实验组的断肢率显著低于对照组,而存活率显著高于对照组(P<0.05).研究表明,丁香酚可明显提高日本沼虾存活率,并显著抑制日本沼虾的应激反应. 相似文献
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Because of the aggressive threaten of heat stroke and a lack of understanding of the mechanism of action, mammal animal models for experimental heat stroke were well developed. During the past 5 decades, anesthetized mouse, rat, rabbit, dog, baboon and monkey were used as animal model for experimental heat stroke. However, anesthetized mammals models have some limitations, such as neuroprotective effect of anesthetic agents, possible disturbance on injury and recovery of stroke animals by anesthetic agents, difficulty of discussing animal behavior before and after heat stroke, it was also difficult for the models to evaluate cognitive function of animal under hot environment. Considering humanitarian, only awaked and unrestrained mouse heat stroke model was accepted so far. Therefore, we also developed an awaked and unrestrained rat heat stroke model, and found it was helpful to evaluate drug effectiveness for animal behavior and cognitive function under hot environment. 相似文献
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《上海生物医学工程》2005,26(4):243-243
需要进行外科手术的病人今后将不必再为术后伤口疼痛发愁。美国加州的I-Flow公司研制出一种简便易用,专为做过手术的病人解除疼痛的设备-ON-Q疼痛缓解系统,只要术后将这种小装置放在手术切口处,就可通过其球形气泵将局部麻醉剂缓缓输入伤口,有效止疼。该系统现已用于实施了子宫切除和剖腹产手术的妇女。 相似文献