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Antiviral activity and pathogenetic targets for seaweed sulfated polysaccharides in herpesvirus infections 总被引:1,自引:0,他引:1
N.?N.?BesednovaEmail author I.?D.?Makarenkova T.?N.?Zvyagintseva T.?I.?Imbs L.?M.?Somova T.?S.?Zaporozhets 《Biochemistry (Moscow) Supplemental Series B: Biomedical Chemistry》2016,10(1):31-42
The review summarizes results of studies of effects of sulfated polysaccharides from seaweed on herpesviruses and the course of herpesvirus infections. Importance of this problem is determined by the prevalence of herpesviruses that can persist in the human body and demonstrate a high degree of immune mimicry and resistance to antiviral drugs. A wide range of physiological action of sulfated polysaccharides, receptor agonists of innate and adaptive immune cells, which possess potent antiviral, antioxidant and anti-inflammatory activities, open the possibility of their use for creation of new generation pharmacological substances and drugs with associated activity for the treatment of herpesvirus infections. 相似文献
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S. A. Alekseeva N. M. Shevchenko M. I. Kusaykin L. P. Ponomorenko V. V. Isakov T. N. Zvyagintseva E. V. Likhoshvai 《Applied Biochemistry and Microbiology》2005,41(2):185-191
Polysaccharide composition of neutral, acid- and alkali-soluble fractions of the diatoms Stephanodiscus meyerii Genkal et Popovsk and Aulacoseira baicalensis (K. Meyer) Simonsen of Lake Baikal has been studied. Neutral polysaccharides were represented by chrysolaminarans (13;16--D-glucans). The chrysolaminaran from S. meyerii consists of the high- and low-molecular-weight fractions (40 and 2–5 kDa, respectively) and contains a large number of -16-bound glucose residues. The chrysolaminaran from A. baicalensis is a low-molecular-weight 13;16--D-glucan containing a small number of -16-bonds, with mannitol being attached to the reducing unit of its chain. Acid- and alkali-soluble polysaccharide fractions are practically absent in S. meyerii. The alkali-soluble fraction from A. baicalensis is a low-molecular-weight (2-kDa) glycoprotein, the carbohydrate moiety of which is represented by a heteropolysaccharide.Translated from Prikladnaya Biokhimiya i Mikrobiologiya, Vol. 41, No. 2, 2005, pp. 213–219.Original Russian Text Copyright © 2005 by Alekseeva, Shevchenko, Kusaykin, Ponomorenko, Isakov, Zvyagintseva, Likhoshvai. 相似文献
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A. M. Urvantseva I. Yu. Bakunina O. I. Nedashkovskaya S. B. Kim T. N. Zvyagintseva 《Applied Biochemistry and Microbiology》2006,42(5):484-491
A search for fucoidan-degrading enzymes and other O-glycosylhydrolases has been performed among 51 strains of marine bacteria of the family Flavobacteriaceae isolated from red, green, and brown algae, as well as from the sea urchin Strongylocentrotus intermedius and the holothurian Apostichopus japonicus. Over 40% of the studied strains synthesized fucoidanases. The marine bacteria Mesonia algae KMM 3909T (an isolate from green alga Acrosiphonia sonderi), as well as Maribacter sp. KMM 6211 and Gramella sp. KMM 6054 (associants of the sea urchin S. intermedius), were the best producers of fucoidanases. Xylose effectively induced the biosynthesis of fucoidanases in these strains. None of the 15 strains of marine bacteria belonging to the genus Arenibacter produced polysaccharide hydrolases. 相似文献
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S. P. Ermakova E. P. Ivanova I. Yu. Bakunina V. V. Mikhailov T. N. Zvyagintseva 《Microbiology》2012,81(3):367-372
The effect of fucoidan, extractive substances from Fucus evanescens and the Laminaria cichorioides protein (an inhibitor of endo-1→3-β-D-glucanase) on the degradation of F. evanescens thallus and on the growth of bacteria involved in this process was studied. The complex of O-glycosyl hydrolases and the level of their enzymatic activity in bacteria cultivated under various conditions depended significantly on the composition of the growth medium. The highest taxonomic diversity was observed for bacteria isolated from the thallus degraded in the control medium (sea water). These bacteria were characterized by very low levels of activity of the enzymes degrading polysaccharides (fucoidan, laminaran, and pustulan). In the presence of 1→3-β-D-glucanase inhibitors, the taxonomic diversity of the microorganisms degrading F. evanescens thallus was decreased, and the activity of O-glycosyl hydrolases (particularly, of fucoidan hydrolases) was increased. 相似文献
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Kusaykin M Bakunina I Sova V Ermakova S Kuznetsova T Besednova N Zaporozhets T Zvyagintseva T 《Biotechnology journal》2008,3(7):904-915
Recent advances in the study of fucoidans, biologically active sulfated alpha-L-fucans of diverse structures and synthesized exclusively by marine organisms, are overviewed. Their structure, biological activity, the products of their enzymatic degradation and the different enzymes of degradation and modification are considered. 相似文献
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Oil degradation by cultures of Rhodococcus erythropolisand Dietzia mariswas found to depend on the NaCl concentration in the medium. Optimal utilization of turbine oil by R. erythropolisand D. mariswas observed at 0.5 and 2 to 5% NaCl concentration, respectively. Mineral oil and a mixture of paraffins (C14–C18) were utilized within a broader range of the medium salinity. As shown by fluorescent microscopy, D. mariscolonies formed on the oil drop surface, whereas R. erythropoliscells penetrated the drops. The strains studied may populate various ecological niches in oil-containing ecosystems. They are promising for the development of microbial preparations for cleaning the environment from oil pollution. 相似文献
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I. S. Zvyagintseva E. G. Surovtseva M. N. Poglazova V. S. Ivoilov S. S. Belyaev 《Microbiology》2001,70(3):270-276
Gas liquid chromatography (GLC) was used for the first time to screen for machine oil–degrading microorganisms. Oil degradation was evaluated from the microorganism respiratory activity during the utilization of oil as the sole carbon and energy source. The results are consistent with those obtained by the conventional weighing method. Substrate specificity of the active strains with respect to different machine oils was studied. Bacterial communities exhibited the highest activity, whereas a Rhodococcus erythropolisstrain was the most active among pure cultures. Various stages of bacterial interaction with oil drops were followed by means of fluorescent microscopy. 相似文献
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Kiseleva MI Balabanova LA Rasskazov VA Zvyagintseva TN 《Marine biotechnology (New York, N.Y.)》2008,10(4):466-470
The effect of 1,3;1,6-beta-D-glucooligo- and polysaccharides with different structures (from 1 to 10 kDa of molecular mass; from 10-25% of beta-1,6-linked glucose residues content) on the developing embryos of sea urchin, Strongylocentrotus intermedius, was evaluated for the screening of potential positive stimulants. 1,3;1,6-beta-D-glucans with a molecular mass of between 6-10 kDa and at concentrations of 0.05-0.25 mg/ml shown the best modulator effect on the sea urchin embryos. 1,3;1,6-beta-D-glucans increased the survival of the sea urchin embryos up to 2.5-fold compared with the control animals. 相似文献