全文获取类型
收费全文 | 13433篇 |
免费 | 1693篇 |
国内免费 | 5324篇 |
出版年
2024年 | 106篇 |
2023年 | 324篇 |
2022年 | 569篇 |
2021年 | 829篇 |
2020年 | 662篇 |
2019年 | 806篇 |
2018年 | 634篇 |
2017年 | 578篇 |
2016年 | 582篇 |
2015年 | 847篇 |
2014年 | 1096篇 |
2013年 | 1070篇 |
2012年 | 1420篇 |
2011年 | 1204篇 |
2010年 | 961篇 |
2009年 | 929篇 |
2008年 | 1074篇 |
2007年 | 1025篇 |
2006年 | 887篇 |
2005年 | 825篇 |
2004年 | 675篇 |
2003年 | 634篇 |
2002年 | 624篇 |
2001年 | 475篇 |
2000年 | 437篇 |
1999年 | 272篇 |
1998年 | 157篇 |
1997年 | 117篇 |
1996年 | 118篇 |
1995年 | 94篇 |
1994年 | 72篇 |
1993年 | 48篇 |
1992年 | 44篇 |
1991年 | 30篇 |
1990年 | 29篇 |
1989年 | 25篇 |
1988年 | 29篇 |
1987年 | 20篇 |
1986年 | 8篇 |
1985年 | 14篇 |
1984年 | 11篇 |
1983年 | 9篇 |
1982年 | 21篇 |
1981年 | 7篇 |
1976年 | 5篇 |
1964年 | 5篇 |
1957年 | 8篇 |
1955年 | 3篇 |
1954年 | 3篇 |
1950年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
Semiparametric Regression in Size-Biased Sampling 总被引:1,自引:0,他引:1
Ying Qing Chen 《Biometrics》2010,66(1):149-158
Summary . Size-biased sampling arises when a positive-valued outcome variable is sampled with selection probability proportional to its size. In this article, we propose a semiparametric linear regression model to analyze size-biased outcomes. In our proposed model, the regression parameters of covariates are of major interest, while the distribution of random errors is unspecified. Under the proposed model, we discover that regression parameters are invariant regardless of size-biased sampling. Following this invariance property, we develop a simple estimation procedure for inferences. Our proposed methods are evaluated in simulation studies and applied to two real data analyses. 相似文献
2.
3.
4.
5.
6.
H. B. OSBORNE A. C. BAKKE J. YU 《Differentiation; research in biological diversity》1982,21(1-3):66-69
A murine erythroleukemic cell line, 745 A4-TG, deficient in hypoxanthine-guanine-phosphoribosyl transferase, can be induced with 3 mM hexamethylene bisacetamide to yield at least 50% of cells undergoing irreversible erythroid differentiation and finally losing capacity for cell divisions. The effects of such induced differentiation of 745 A4-TG on its ability to form viable and proliferating hybrids when fused with 3T3 1T22 fibroblasts were investigated. We found that when the induced 745 A4-TG cells were used, more continuously proliferating hybrids were obtained than could be accounted for by the residual uninduced cells which remained in these induced preparations. This suggests that some of the induced 745 A4-TG cells, when fused with 3T3 1T22 reverted from the induced phenotype of a limited capacity for cell proliferation to an uninduced state of continuous proliferation. This observation was further confirmed with the use of fully differentiated 745 A4-TG cells, which were obtained after selection with a bromodeoxyuridine suicide treatment to eliminate the uninduced and the partially differentiated cells in the preparations. When these selected, fully differentiated cells, as characterized by their lack of proliferation capacity and thymidine kinase activity, were fused with 3T3 1T22 (also deficient in thymidine kinase), it was found that not only were viable hybrid colonies obtained in a selection medium, which precluded the proliferation of either parental cells, but these hybrids continued to proliferate for more than two months in selection medium. These data thus confirmed that some fully differentiated erythroleukemic nucleus components in the hybrids were reactivated to regain capacity for cell proliferation and to dedifferentiate to synthesize thymidine kinase for survival in the selection medium. The lack of hemoglobin synthesis by these hybrids also indicates dedifferention of these murine erythroleukemic components in the hybrids. 相似文献
7.
8.
Intermittent tongue, lip and cheek forces influence precise tooth position, so we here examine the possibility that tissue remodelling driven by functional bite-force-induced jaw-strain accounts for tooth eruption. Notably, although a separate true ‘eruptive force’ is widely assumed, there is little direct evidence for such a force. We constructed a three dimensional finite element model from axial computerized tomography of an 8 year old child mandible containing 12 erupted and 8 unerupted teeth. Tissues modelled included: cortical bone, cancellous bone, soft tissue dental follicle, periodontal ligament, enamel, dentine, pulp and articular cartilage. Strain and hydrostatic stress during incisive and unilateral molar bite force were modelled, with force applied via medial and lateral pterygoid, temporalis, masseter and digastric muscles. Strain was maximal in the soft tissue follicle as opposed to surrounding bone, consistent with follicle as an effective mechanosensor. Initial numerical analysis of dental follicle soft tissue overlying crowns and beneath the roots of unerupted teeth was of volume and hydrostatic stress. To numerically evaluate biological significance of differing hydrostatic stress levels normalized for variable finite element volume, ‘biological response units’ in Nmm were defined and calculated by multiplication of hydrostatic stress and volume for each finite element. Graphical representations revealed similar overall responses for individual teeth regardless if incisive or right molar bite force was studied. There was general compression in the soft tissues over crowns of most unerupted teeth, and general tension in the soft tissues beneath roots. Not conforming to this pattern were the unerupted second molars, which do not erupt at this developmental stage. Data support a new hypothesis for tooth eruption, in which the follicular soft tissues detect bite-force-induced bone-strain, and direct bone remodelling at the inner surface of the surrounding bony crypt, with the effect of enabling tooth eruption into the mouth. 相似文献
9.
10.