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Akashiba Tsuneto Inoue Yuichi Uchimura Naohisa Ohi Motoharu Kasai Takatoshi Kawana Fusae Sakurai Shigeru Takegami Misa Tachikawa Ryo Tanigawa Takeshi Chiba Shintaro Chin Kazuo Tsuiki Satoru Tonogi Morio Nakamura Hiroshi Nakayama Takeo Narui Koji Yagi Tomoko Yamauchi Motoo Yamashiro Yoshihiro Yoshida Masahiro Oga Toru Tomita Yasuhiro Hamada Satoshi Murase Kimihiko Mori Hiroyuki Wada Hiroo Uchiyama Makoto Ogawa Hiromasa Sato Kazumichi Nakata Seiichi Mishima Kazuo Momomura Shin-Ichi 《Sleep and biological rhythms》2022,20(1):5-37
Sleep and Biological Rhythms - The prevalence of sleep-disordered breathing (SDB) is reportedly very high. Among SDBs, the incidence of obstructive sleep apnea (OSA) is higher than previously... 相似文献
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Kengo Kato Manami Ozaki Kumiko Nakai Maki Nagasaki Junya Nakajima Ryosuke Koshi Hideki Tanaka Takayuki Kawato Morio Tonogi 《Current issues in molecular biology》2021,43(3):1451
Azithromycin displays immunomodulatory and anti-inflammatory effects in addition to broad-spectrum antimicrobial activity and is used to treat inflammatory diseases, including respiratory and odontogenic infections. Few studies have reported the effect of azithromycin therapy on bone remodeling processes. The aim of this study was to examine the effects of azithromycin on the osteogenic function of osteoblasts using osteoblast-like MC3T3-E1 cells. Cells were cultured in the presence of 0, 0.1, 1, and 10 µg/mL azithromycin, and cell proliferation and alkaline phosphatase (ALPase) activity were determined. In vitro mineralized nodule formation was detected with alizarin red staining. The expression of collagenous and non-collagenous bone matrix protein was determined using real-time PCR or enzyme-linked immunosorbent assays. In cells cultured with 10 µg/mL azithromycin, the ALPase activity and mineralized nodule formation decreased, while the type I collagen, bone sialoprotein, osteocalcin, and osteopontin mRNA expression as well as osteopontin and phosphorylated osteopontin levels increased. These results suggest that a high azithromycin concentration (10 µg/mL) suppresses mineralized nodule formation by decreasing ALPase activity and increasing osteopontin production, whereas low concentrations (≤l.0 µg/mL) have no effect on osteogenic function in osteoblastic MC3T3-E1 cells. 相似文献
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