排序方式: 共有2条查询结果,搜索用时 0 毫秒
1
1.
Manochehr Shahabi Eva Schirmer Karem Shanab Theerachart Leepasert Jana Ruzicka Wolfgang Holzer Helmut Spreitzer Babette Aicher Peter Schmidt Lars Blumenstein Gilbert Müller Eckhard Günther 《Bioorganic & medicinal chemistry letters》2013,23(6):1846-1852
A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested. 相似文献
2.
Theerachart Leepasert Manochehr Shahabi Karem Shanab Eva Schirmer Wolfgang Holzer Helmut Spreitzer Babette Aicher Gilbert Müller Eckhard Günther 《Bioorganic & medicinal chemistry letters》2013,23(19):5264-5266
A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least three different cell lines. 相似文献
1