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Chitra B. Nair K. N. Anith Janardhanan Sreekumar 《World journal of microbiology & biotechnology》2007,23(8):1183-1187
Four rhizobacterial strains and acibenzolar-S-methyl (ASM), a chemical activator, which suppressed foliar blight of amaranthus (Amaranthus tricolor L.) caused by Rhizoctonia solani Kühn were evaluated for their effect on plant growth. The experiments were performed both under sterile and non-sterile soil
conditions, in the presence or absence of the pathogen. In all cases, plants treated with ASM showed significant reduction
in growth, as determined by shoot length, and shoot and root dry weight when compared to other treatments. The growth retardation
effect of ASM was more profound with respect to shoot length. Reduction in shoot length was least when plants were treated
with a combination of the chemical activator and Pseudomonas putida 89B61 under non-sterile soil conditions in the absence of the pathogen. Both under sterile and non-sterile soil conditions,
in the presence of the pathogen, reduction in shoot length due to application of ASM was diminished significantly when plants
were treated with rhizobacterial strain Pseudomonas fluorescens PN026R. Combined use of plant growth-promoting rhizobacteria (PGPR) and ASM was found to be beneficial as the growth retardation
effect of the plant defense activator was reduced by the growth-promoting ability of the rhizobacteria. 相似文献
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N Sreeram U Trieschmann M Khalil M Emmel 《Indian pacing and electrophysiology journal》2010,10(6):257-273
Identifying the young patient at risk of malignant arrhythmias and sudden cardiac death remains a challenge. It is increasingly recognised that sudden death, syncope and aborted cardiac arrest at a young age in patients with a structurally normal heart may be the result of various ion channel disorders - the channelopathies. The approach to risk stratification involves a combination of the clinical presentation, taken in conjunction with the family history, genetic testing, invasive electrophysiological studies or other provocative tests where appropriate and feasible. A logical approach to risk stratification in some of the commoner channelopathies seen in paediatric practice is presented. 相似文献
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Giammario Ragnedda Giulio Disanto Gavin Giovannoni George C. Ebers Stefano Sotgiu Sreeram V. Ramagopalan 《PloS one》2012,7(10)
Genetic factors play an important role in determining the risk of multiple sclerosis (MS). The strongest genetic association in MS is located within the major histocompatibility complex class II region (MHC), but more than 50 MS loci of modest effect located outside the MHC have now been identified. However, the relative candidate genes that underlie these associations and their functions are largely unknown. We conducted a protein-protein interaction (PPI) analysis of gene products coded in loci recently reported to be MS associated at the genome-wide significance level and in loci suggestive of MS association. Our aim was to identify which suggestive regions are more likely to be truly associated, which genes are mostly implicated in the PPI network and their expression profile. From three recent independent association studies, SNPs were considered and divided into significant and suggestive depending on the strength of the statistical association. Using the Disease Association Protein-Protein Link Evaluator tool we found that direct interactions among genetic products were significantly higher than expected by chance when considering both significant regions alone (p<0.0002) and significant plus suggestive (p<0.007). The number of genes involved in the network was 43. Of these, 23 were located within suggestive regions and many of them directly interacted with proteins coded within significant regions. These included genes such as SYK, IL-6, CSF2RB, FCLR3, EIF4EBP2 and CHST12. Using the gene portal BioGPS, we tested the expression of these genes in 24 different tissues and found the highest values among immune-related cells as compared to non-immune tissues (p<0.001). A gene ontology analysis confirmed the immune-related functions of these genes. In conclusion, loci currently suggestive of MS association interact with and have similar expression profiles and function as those significantly associated, highlighting the fact that more common variants remain to be found to be associated to MS. 相似文献
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Ramagopalan SV Herrera BM Bell JT Dyment DA Deluca GC Lincoln MR Orton SM Chao MJ Sadovnick AD Ebers GC 《Human genetics》2008,122(6):661-663
Chen et al. found that the CA haplotype of protein C -1654C/T and -1641G/A was associated with increased risk of death and
organ dysfunction in Chinese Han patients with severe sepsis (Hum Genet 123:281–287, 2008). We similarly tested for association
of the C allele of protein C 673 T/C (rs2069912) (linkage disequilibrium with the CA haplotype, D′ = 100%) in a cohort of 100 North American East Asians with severe sepsis. The C allele was associated with increased mortality
and organ dysfunction, consistent with Chen et al.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Support: Sirius Genomics Inc., Canadian Institutes of Health Research. Keith R. Walley is a Michael Smith Foundation for Health
Research Distinguished Scholar. 相似文献
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Many advances have been made in the use of implantable diagnostic and therapeutic devices in adults. In children the indications for and diagnostic and therapeutic value of these devices still have to be determined.Our aim is to provide an overview of the clinical use of diagnostic and therapeutic devices in children. The role of implantable loop recorders (ILR), the feasibility and safety of transvenous pacing in neonates, the value of permanent pacing in children with recurrent syncope or reflex anoxic seizures and the role of implantable cardioverter defibrillator devices are highlighted with relevant case histories. 相似文献
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P. R. Shidhi F. Nadiya V. C. Biju Sheethal Vijayan Anu Sasi C. L. Vipin Akhil Janardhanan S. Aswathy Veena S. Rajan Achuthsankar S. Nair 《Physiology and Molecular Biology of Plants》2021,27(8):1867
Evolvulus alsinoides, belonging to the family Convolvulaceae, is an important medicinal plant widely used as a nootropic in the Indian traditional medicine system. In the genus Evolvulus, no research on the chloroplast genome has been published. Hence, the present study focuses on annotation, characterization, identification of mutational hotspots, and phylogenetic analysis in the complete chloroplast genome (cp) of E. alsinoides. Genome comparison and evolutionary dynamics were performed with the species of Solanales. The cp genome has 114 genes (80 protein-coding genes, 30 transfer RNA, and 4 ribosomal RNA genes) that were unique with total genome size of 157,015 bp. The cp genome possesses 69 RNA editing sites and 44 simple sequence repeats (SSRs). Predicted SSRs were randomly selected and validated experimentally. Six divergent hotspots such as trnQ-UUG, trnF-GAA, psaI, clpP, ndhF, and ycf1 were discovered from the cp genome. These microsatellites and divergent hot spot sequences of the Taxa ‘Evolvulus’ could be employed as molecular markers for species identification and genetic divergence investigations. The LSC area was found to be more conserved than the SSC and IR region in genome comparison. The IR contraction and expansion studies show that nine genes rpl2, rpl23, ycf1, ycf2, ycf1, ndhF, ndhA, matK, and psbK were present in the IR-LSC and IR-SSC boundaries of the cp genome. Fifty-four protein-coding genes in the cp genome were under negative selection pressure, indicating that they were well conserved and were undergoing purifying selection. The phylogenetic analysis reveals that E. alsinoides is closely related to the genus Cressa with some divergence from the genus Ipomoea. This is the first time the chloroplast genome of the genus Evolvulus has been published. The findings of the present study and chloroplast genome data could be a valuable resource for future studies in population genetics, genetic diversity, and evolutionary relationship of the family Convolvulaceae.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12298-021-01051-w. 相似文献
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