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Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2''''-deoxycytidine 总被引:2,自引:0,他引:2
~~Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine@Chien Chung CHANG$Department of Immunology,Roswell Park Cancer Institute,Buffalo.NY 14263,USA
@Soldano FERRONE$Department of Immunology,R… 相似文献
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TOSHIRO KAGESHITA ZHI JIAN CHEN JIN-WOO KIM MIKIHIRO KUSAMA ULANA MARIA KEKISH TRACY TRUJILLO MASSIMO TEMPONI ABRAHAM MITTELMAN SOLDANO FERRONE 《Pigment cell & melanoma research》1988,1(Z1):185-191
Following a discussion of the rationale underlying the selection of human melanoma to test the usefulness of anti-idiotypic monoclonal antibodies in the therapy of solid tumors, the development of the anti-idiotypic monoclonal antibody MoAb) MF11–30 is described. This antibody recognizes a private idiotope within the antigen-combining site of the immunizing antihuman high molecular weight melanoma-associated antigen MoAb 225.28. The results of a phase I clinical trial with the MoAb MF11–30 in patients with advanced melanoma are described. The lack of toxic effects and the minor responses in six patients suggest that these studies should be extended to a larger number of patients with an emphasis on the analysis of the mechanisms underlying the clinical response. 相似文献
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ATSUKO KOMURA TAKESHI TOKUHISA TOSHIO NAKAGAWA AKIHIRO SASASE MASAMITSU ICHIHASHI SOLDANO FERRONE YUTAKA MISHIMA 《Pigment cell & melanoma research》1989,2(4):259-263
We previously established methods which have enabled us to target a sufficient number of 10B atoms on human melanoma cells to destroy them by thermal neutron irradiation. Monoclonal antibodies were here used as vector of 10B atoms on the target cell. Thermal neutrons require at least 10910B atoms to destroy the cell. In order to accumulate an adequate number of 10B atoms on target cells, our first approach was to make an effective compound that contains 12 atoms of 10B in a molecule. The second step was to conjugate the compound with an avidin molecule (10B12-avidin). One molecule of the 10B12-avidin carries about 30 atoms of 10B. This 10B12-avidin can be specifically targeted on human melanoma cells by biotinated monoclonal antibodies specific for the cells. Furthermore, the number of 10B atoms on target cells can be augmented by a hapten-antihapten monoclonal antibody system. The cultured human melanoma cells treated with these methods were damaged by thermal neutron irradiation. This is the first study that indicates thermal neutrons do injure target cells boronated by monoclonal antibodies. 相似文献
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SEBASTIANO GATTONI-CELLI RANDOLPH H. BYERS LIDO CALORINI SOLDANO FERRONE 《Pigment cell & melanoma research》1993,6(6):381-384
Metastases from certain primary tumors frequently exhibit specific organ preference. Animal models have been developed to induce in a reproducible fashion the formation of organ-specific metastases by malignant melanoma cells. Some of these models rely on the use of immunodeficient mice, which can support the growth of murine as well as human malignant melanomas. Moreover, immunodeficient mice, because of their diminished ability to mount an effective immune response, allow the expression of malignant properties (e.g., preferential colonization of certain organs), which are intrinsic to transplanted melanoma cells. This review discusses the relevant factors (and limitations) of some of the animal models used to study the in vivo properties of melanoma cells. 相似文献
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