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Caicedo-Lopez Laura Helena Guevara-Gonzalez Ramon G. Ramirez-Jimenez Aurea K. Feregrino-Perez Ana A. Contreras-Medina Luis Miguel 《Phytochemistry Reviews》2022,21(6):1941-1968
Phytochemistry Reviews - Capsaicinoids (CAPs) are compounds synthesized and accumulated exclusively in pepper fruits. They are known as health-promoting compounds, and upbringing approaches to... 相似文献
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Listeriolysin O expressed in a bacterial vaccine suppresses CD4+CD25high regulatory T cell function in vivo 总被引:2,自引:0,他引:2
Nitcheu-Tefit J Dai MS Critchley-Thorne RJ Ramirez-Jimenez F Xu M Conchon S Ferry N Stauss HJ Vassaux G 《Journal of immunology (Baltimore, Md. : 1950)》2007,179(3):1532-1541
CD4(+)CD25(high) regulatory T cells (Treg) protect the host from autoimmune diseases but are also obstacles against cancer therapies. An ideal cancer vaccine would stimulate specific cytotoxic responses and reduce/suppress Treg function. In this study, we showed that Escherichia coli expressing listeriolysin O and OVA (E. coli LLO/OVA) demonstrated remarkable levels of protection against OVA-expressing tumor cells. By contrast, E. coli expressing OVA only (E. coli OVA) showed poor protection. High-avidity OVA-specific CTL were induced in E. coli LLO/OVA-vaccinated mice, and CD8(+) depletion--but not NK cell depletion, abolished the antitumor activity of the E. coli LLO/OVA vaccine. Phenotypic analysis of T cells following vaccination with either vaccine revealed preferential generation of CD44(high)CD62L(low) CD8(+) effector memory T cells over CD44(high)CD62L(high) central memory T cells. Unexpectedly, CD4(+) depletion turned E. coli OVA into a vaccine as effective as E. coli LLO/OVA suggesting that a subset of CD4(+) cells suppressed the CD8(+) T cell-mediated antitumor response. Further depletion experiments demonstrated that these suppressive cells consisted of CD4(+)CD25(high) regulatory T cells. We therefore assessed these vaccines for Treg function and found that although CD4(+)CD25(high) expansion and Foxp3 expression within this population was similar in all groups of mice, Treg cells from E. coli LLO/OVA-vaccinated animals were unable to suppress conventional T cells proliferation. These findings provide the first evidence that LLO expression affects Treg cell function and may have important implications for enhancing antitumor vaccination strategies in humans. 相似文献
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