排序方式: 共有9条查询结果,搜索用时 15 毫秒
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M. E. Palkeeva M. V. Sidorova A. S. Molokoedov A. A. Az’muko Zh. D. Bespalova T. V. Sharf E. N. Mamochkina E. E. Efremov M. M. Rogova N. A. Mironova K. A. Zykov S. P. Golitsyn 《Russian Journal of Bioorganic Chemistry》2013,39(3):252-258
Fragments corresponding to the 83–98 sequence of the first extracellular loop and to the 168–192 and 171–182 sequences of the second extracellular loop of the M2-muscarinic receptor (antibodies to this receptor could be markers of early symptoms of heart disorders) were synthesized by solid phase method using the Fmoc-SPPS strategy. A new conformational antigen with the natural location of the disulfide bridge was prepared by selective formation of disulfide bond between the corresponding cysteine residues in the synthe-sized peptides and characterized. The comparative analysis of reactivity of the synthesized peptides towards sera from patients which had no organic heart disease was performed. A new conformational antigen was effectively bound to the sera from patients with idiopathic arrhythmias, but without symptoms of organic heart disease. 相似文献
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Sidorova M. V. Palkeeva M. E. Avdeev D. V. Molokoedov A. S. Ovchinnikov M. V. Azmuko A. A. Serebryakova L. I. Veselova O. M. Studneva I. M. Pisarenko O. I. 《Russian Journal of Bioorganic Chemistry》2020,46(1):32-42
Russian Journal of Bioorganic Chemistry - The full-length rat galanin (GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2, G29) was prepared by the solid phase peptide synthesis using the Fmoc-strategy. The peptide... 相似文献
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Studneva Irina M. Veselova Oksana M. Dobrokhotov Igor V. Serebryakova Larisa I. Palkeeva Marina E. Molokoedov Alexander S. Azmuko Andrey A. Ovchinnikov Michael V. Sidorova Maria V. Pisarenko Oleg I. 《Biochemistry. Biokhimii?a》2022,87(4):346-355
Biochemistry (Moscow) - Neuropeptide galanin and its N-terminal fragments reduce the generation of reactive oxygen species and normalize metabolic and antioxidant states of myocardium in... 相似文献
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Sidorova M. V. Palkeeva M. E. Azmuko A. A. Ovchinnikov M. V. Molokoedov A. S. Bushuev V. N. Pisarenko O. I. 《Russian Journal of Bioorganic Chemistry》2019,45(1):18-26
Russian Journal of Bioorganic Chemistry - A method for the solid-phase synthesis of the apelin-12 analog has been developed using the Fmoc methodology in combination with the temporary protection... 相似文献
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Avdeev D. V. Ovchinnikov M. V. Dudkina Y. S. Molokoedov A. S. Azmuko A. A. Palkeeva M. E. Sidorova M. V. 《Russian Journal of Bioorganic Chemistry》2021,47(6):1241-1248
Russian Journal of Bioorganic Chemistry - This work is devoted to the large-scale solid-phase synthesis (SPS) of Atosiban, Mpa1-D-Tyr(OEt)-Ile-Thr-Asn-Cys6-Pro-Orn-Gly-NH2 cyclic 1,6 disulfide, the... 相似文献
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M.?V.?SidorovaEmail author M.?E.?Palkeeva A.?A.?Az’muko M.?V.?Ovchinnikov A.?S.?Molokoedov T.?V.?Sharf E.?E.?Efremov S.?P.?Golitsyn 《Russian Journal of Bioorganic Chemistry》2017,43(4):351-358
The P26 peptide corresponding to the 197–222 sequence of the second extracellular loop of the β1-adrenoreceptor (β1-AR) was synthesized by solid-phase fragment condensation on the Wang polymer. Pentapeptide fragments were prepared on the 2-chlorotrityl resin. The racemization degree of the C-terminal alanine residue of the pentapeptide was experimentally evaluated for the synthetic H-Glu-Ser-Asp-Glu-Ala-Arg-OH hexapeptide β1-АR-(202–207) which was prepared by the 5 + 1 fragment condensation with the use of various condensing agents. A content of the diastereoisomeric peptide in the products of the fragment condensation was determined by HPLC on a reversed phase. The D-alanine-containing hexapeptide was specially synthesized and used for a comparison. The minimum racemization degree of the C-terminal alanine residue was observed if complex F was applied to the synthesis of the hexapeptide. 相似文献
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Sidorova M. V. Dudkina U. S. Avdeev D. V. Palkeeva M. E. Molokoedov A. S. Ovchinnikov M. V. Azmuko A. A. Grechishnikov S. B. Kudryavtseva E. V. Bushuev V. N. Arefieva T. I. 《Russian Journal of Bioorganic Chemistry》2020,46(4):520-529
Russian Journal of Bioorganic Chemistry - The solid phase synthesis (SPS) of the ingramon peptide antagonist of the human monocyte chemoattractant protein-1... 相似文献
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Pisarenko Oleg I. Studneva Irina M. Serebryakova Larisa I. Timoshin Alexandr A. Konovalova Galina G. Lankin Vadim Z. Tihaze Alla K. Veselova Oksana M. Dobrokhotov Igor V. Lyubimov Roman O. Sidorova Mariya V. Palkeeva Marina E. Molokoedov Alexandr S. 《Biochemistry. Biokhimii?a》2021,86(4):496-505
Biochemistry (Moscow) - Antioxidant properties of rat galanin GWTLNSAGYLLGPHAIDNHRSFSDKHGLT-NH2 (Gal), N-terminal fragment of galanin (2-15 aa) WTLNSAGYLLGPHA (G1), and its modified analogue... 相似文献
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Palkeeva M. E. Sidorova M. V. Molokoedov A. S. Ovchinnikov M. V. Az’muko A. A. Serebryakova L. I. Veselova O. M. Studneva I. M. Pisarenko O. I. 《Russian Journal of Bioorganic Chemistry》2019,45(5):353-360
Russian Journal of Bioorganic Chemistry - New peptide analogs of galanin corresponding to fragments of the N-terminal sequence were synthesized by an automatic solid-phase method using... 相似文献
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