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1.
Merve Dursun Esra Bilir Kubilay Kaymaz Sibel Sakarya 《The Yale journal of biology and medicine》2021,94(1):41
Pre-participation screening (PPS) is crucial for assessing the competitive athletes since their risk of sudden death is higher than non-athletes. In Turkey, PPS is performed at the primary health care setting by primary care physicians (PCPs) who are family medicine specialists (FMSs) or general practitioners (GPs). Although there are national guidelines, there is no legal regulation for this process. This study aims to evaluate PCPs’ knowledge, experience, and approach about PPS. We prepared an online survey for PCPs and used non-probabilistic sampling. PPS attitudes and practices were analyzed and compared according to factors such as experience, education, and being GP or FMS. Of the 214 PCPs included in the study, 39.3% were female. The mean age was 44.9 years (SD:8.88). The average work experience was 7.9 years. Most participants were aware of their authorization to perform PPS (89.7%) and had previously prepared it (90.2%). However, 6.5% of them felt confident in performing PPS. Only 13.1% were aware of the guidelines. Almost 25% of the participants stated being informed about the subject at some part of their career, but this did not affect the confidence or referral decisions. In addition to medical history and physical examination, further testing was considered necessary by 96.3% of the participants. Significantly more tests were ordered by GPs than FMSs (p=0.026 and p=0.011, respectively). The accurate referral decision ratio was 59.3%, without difference between FMSs and GPs (p=0.216). We found that awareness of the guidelines was low among PCPs who lack confidence in PPS. These factors collectively increased the tendency for unnecessary further testing and referral. Therefore, the PPS implementation into medical school and residency curriculums and national legal regulation for the process is a necessity in Turkey. 相似文献
2.
Ekatherina Serysheva Hebist Berhane Luca Grumolato Kubilay Demir Sophie Balmer Maxime Bodak Michael Boutros Stuart Aaronson Marek Mlodzik Andreas Jenny 《EMBO reports》2013,14(8):718-725
Wnt/β-catenin signalling is central to development and its regulation is essential in preventing cancer. Using phosphorylation of Dishevelled as readout of pathway activation, we identified Drosophila Wnk kinase as a new regulator of canonical Wnt/β-catenin signalling. WNK kinases are known for regulating ion co-transporters associated with hypertension disorders. We demonstrate that wnk loss-of-function phenotypes resemble canonical Wnt pathway mutants, while Wnk overexpression causes gain-of-function canonical Wnt-signalling phenotypes. Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling. 相似文献
3.
Protective effects of ascorbic acid, Dl-α-tocopherol acetate, and sodium selenate on ethanol-induced gastric mucosal injury of rats 总被引:2,自引:0,他引:2
Ozdil S Yanardag R Koyuturk M Bolkent S Arbak S 《Biological trace element research》2004,99(1-3):173-189
In this study, the effect of ascorbic acid (vitamin C), Dl-α-tocopherol acetate (vitamin E), and sodium selenate (selenium) on ethanol-induced gastric mucosal injury in rats was investigated
morphologically and biochemically. The gastric mucosal injury was produced by administration of 1 mL of absolute ethanol to
each rat. Animals received vitamin C (250 mg/kg), vitamin E (250 mg/kg), and selenium (0.5 mg/kg) for 3 d 1 h prior to the
administration of absolute ethanol. In gastric mucosa of rats given ethanol according to control groups, neuronal nitric oxide
expression decreased. This immunoreactivity was much lower in the group given ethanol+vitamin C+vitamin E+selenium than the
control group and the ethanol-induced group. Scanning electron microscopic evaluation of the ethanol-induced group, when compared
to control groups, revealed degenerative changes in gastric mucosa, whereas a good arrangement in surface topography of gastric
mucosa in the group given ethanol + vitamin C+vitamin E + selenium was observed. In the group administered ethanol, a reduction
of the stomach glutathione (GSH) and serum total protein levels and increases in serum sialic acid, triglycerides, and stomach
lipid peroxidation (LPO) levels were observed. Vitamin C+vitamin E+Se administration to alcohol-treated rats significantly
increased the serum total protein, triglyceride levels, and stomach GSH levels and significantly lowered the levels of serum
sialic acid and stomach LPO compared to untreated alcohol-supplemented rats. As a result of these findings, we can say that
the combination of vitamin C, vitamin E, and selenium has a protective effect on ethanol-induced gastric mucosal injury of
rats. 相似文献
4.
Background
Reconstruction of the head and neck after adequate resection of primary tumor and neck dissection is a challenge. It should be performed at one sitting in advanced tumors. Defects caused by the resection should be closed with flaps which match in color, texture and hair bearing characteristics with the face. Cervicopectoral flap is a one such flap from chest and neck skin mainly used to cover the cheek defects. 相似文献5.
This study demonstrates the debilitative effect of a coelomic gregarine, Diplocystis tipulae, on Tipula paludosa. The larvae were provided contaminated fresh grass leaves from a field where 40.0% of T. paludosa larvae were infected by this pathogen. Resultant infected larvae were separated into four groups according to infection level. Analysing their weights, lengths, and weight/length ratios showed that larval size decreased as infection level increased. Differences, especially at the lower and upper levels of the infection levels, were statistically significant. It was concluded that infection by D. tipulae affected the size of T. paludosa larvae resulting in smaller individuals. 相似文献
6.
7.
Durmaz R Ozden H Kanbak G Aral E Arslan OC Kartkaya K Uzuner K 《Neurochemical research》2008,33(9):1683-1691
We hypothesized that dexanabinol can prevent neuronal death by protecting neuronal lysosomes from nitric oxide (NO)-mediated
toxicity, and in turn, by suppressing the release of cathepsins during cerebral ischemia. Focal cerebral ischemia was induced
in two sets of animals by permanent middle cerebral artery occlusion. The first set was used to monitor NO concentration and
cathepsin activity, while the second was used for histological examination with hematoxylin and eosin, and TUNEL staining.
In post-ischemic brain tissue, NO content and cathepsin B and L activity increased (p < 0.05). Dexanabinol treatment reduced NO concentration and cathepsin activity to the control level (p > 0.05). The number of eosinophilic and apoptotic neurons increased in the post-ischemic cerebral cortex (p < 0.05). However, dexanabinol treatment lowered both of these (p < 0.05). We conclude that dexanabinol might be a useful agent for the treatment of stroke patients. 相似文献
8.
Teoman Kankılıç Perinçek Seçkinozan Şeker Tolga Kankılıç Kubilay Toyran Jan Zima 《Zoology in the Middle East.》2017,63(3):181-188
A new karyotype for blind mole rats was recorded in Tunceli province in Eastern Turkey. The karyotype contained 44 chromosomes, including 13 biarmed pairs, 7 acrocentric pairs, and one heteromorphic pair with a submetacentric and an acrocentric homologue in the autosomal complement (FNa=69). The X chromosome was submetacentric and the Y chromosome medium-sized subtelocentric (FN=73). Distinct dark centromeric C-bands were observed on most of the biarmed and three pairs of the acrocentric autosomes. The NORs were detected on short arms of three subtelocentric pairs and one acrocentric pair of autosomes. The diploid number of chromosomes and the karyotype characteristics observed are obviously unique among hitherto studied populations of blind mole rats and the complement can be evaluated as a new chromosome race of Nannospalax xanthodon. The distribution ranges of individual chromosome races of the species recorded in Eastern Anatolia are revised and possible interracial hybridization is discussed in respect of the finding of a new race. 相似文献
9.
Neumann F Kubuschok B Ertan K Schormann C Stevanovic S Preuss KD Schmidt W Pfreundschuh M 《Cancer immunology, immunotherapy : CII》2011,60(9):1333-1346
Background
Antigen-derived HLA class I-restricted peptides can generate specific CD8+ T-cell responses in vivo and are therefore often used as vaccines for patients with cancer. However, only occasional objective clinical responses have been reported suggesting the necessity of CD4+ T-cell help and possibly antibodies for the induction of an effective anti-tumor immunity in vivo. The SSX2 gene encodes the cancer testis antigen (CTA) HOM-MEL-40/SSX2, which is frequently expressed in a wide spectrum of cancers. Both humoral and cellular immune responses against SSX2 have been described making SSX2 an attractive candidate for vaccine trials.Methods
SYFPEITHI algorithm was used to predict five pentadecamer peptides with a high binding probability for six selected HLA-DRB1 subtypes (*0101, *0301, *0401, *0701, *1101, *1501) which are prevalent in the Caucasian population.Results
Using peripheral blood cells of 13 cancer patients and 5 healthy controls, the HOM-MEL-40/SSX2-derived peptide p101-111 was identified as an epitope with dual immunogenicity for both CD4+ helper and cytotoxic CD8+ T cells. This epitope also reacted with anti-SSX2 antibodies in the serum of a patient with breast cancer. Most remarkably, SSX2/p101-111 simultaneously induced specific CD8, CD4, and antibody responses in vitro.Conclusions
p101-111 is the first CTA-derived peptide which induces CD4+, CD8+, and B-cell responses in vitro. This triple-immunogenic peptide represents an attractive vaccine candidate for the induction of effective anti-tumor immunity. 相似文献10.
Scott A. Lear Koon Teo Danijela Gasevic Xiaohe Zhang Paul P. Poirier Sumathy Rangarajan Pamela Seron Roya Kelishadi Azmi Mohd Tamil Annamarie Kruger Romaina Iqbal Hani Swidan Diego Gómez-Arbeláez Rita Yusuf Jephat Chifamba V. Raman Kutty Kubilay Karsidag Rajesh Kumar Wei Li Andrzej Szuba Alvaro Avezum Rafael Diaz Sonia S. Anand Annika Rosengren Salim Yusuf 《CMAJ》2014,186(4):258-266