全文获取类型
收费全文 | 319篇 |
免费 | 16篇 |
国内免费 | 1篇 |
专业分类
336篇 |
出版年
2023年 | 2篇 |
2022年 | 17篇 |
2021年 | 24篇 |
2020年 | 27篇 |
2019年 | 26篇 |
2018年 | 24篇 |
2017年 | 16篇 |
2016年 | 15篇 |
2015年 | 21篇 |
2014年 | 17篇 |
2013年 | 32篇 |
2012年 | 17篇 |
2011年 | 23篇 |
2010年 | 19篇 |
2009年 | 18篇 |
2008年 | 6篇 |
2007年 | 4篇 |
2006年 | 7篇 |
2005年 | 7篇 |
2004年 | 4篇 |
2002年 | 2篇 |
1999年 | 3篇 |
1998年 | 1篇 |
1994年 | 1篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有336条查询结果,搜索用时 15 毫秒
1.
2.
Oxidative stress‐induced renal telomere shortening as a mechanism of cyclosporine‐induced nephrotoxicity 下载免费PDF全文
Sina Raeisi Amir Ghorbanihaghjo Hassan Argani Siavoush Dastmalchi Morteza Seifi Babollah Ghasemi Teimour Ghazizadeh Mehran Mesgari Abbasi Pouran Karimi 《Journal of biochemical and molecular toxicology》2018,32(8)
Due to the association of oxidative stress and telomere shortening, it was aimed in the present study to investigate the possibility whether cyclosporine‐A exerts its nephrotoxic side effects via induction of oxidative stress‐induced renal telomere shortening and senescent phenotype in renal tissues of rats. Renal oxidative stress markers, 8‐hydroxydeoxyguanosine, malondialdehyde, and protein carbonyl groups were measured by standard methods. Telomere length and telomerase activity were also evaluated in kidney tissue samples. Results showed that cyclosporine‐A treatment significantly (P < 0.05) enhanced renal malondialdehyde, 8‐hydroxydeoxyguanosine, and protein carbonyl groups levels, decreased renal telomere length, and deteriorated renal function compared with the controls. Renal telomerase activity was not affected by cyclosporine‐A. Renal telomere length could be considered as an important parameter of both oxidative stress and kidney function. Telomere shortening and accelerated kidney aging may be caused by cyclosporine‐induced oxidative stress, indicating the potential mechanism of cyclosporine‐induced nephrotoxicity. 相似文献
3.
Morteza Gholami Faezeh Ghanati Ali Reza Fakhari Laleh Yousefzadeh Borojeni Masoumeh Safari 《Chirality》2013,25(10):583-588
Ornithine (Orn) plays an essential role in the metabolism of plant cells through incorporation in polyamines biosynthesis, the urea cycle and nitrogen metabolism. Herein, we show that Orn enantiomers have different effects on anti‐oxidant enzymes activities, polyamines and proline biosynthesis and also an alleviation effect of osmotic stresses on tobacco cells. The type of stress has a significant impact on the function of L‐ and D‐Orn for improvement of the stress effect on the cells. Under saline conditions, both enantiomers restored cell growth, though D‐Orn was more beneficial to some extent. This was accompanied with a higher biosynthesis of putrescine, proline, and up‐regulated activity of certain anti‐oxidant enzymes by D‐Orn. Under drought stress conditions, a distinct differential behavior emerged and only L‐Orn showed an alleviative effect on the cell growth. Regulation of hydrogen peroxide content via the activity of catalase/peroxidase and production of osmolytes, e.g., proline and fructans, was dependent on the type of enantiomers. Activity of anti‐oxidant enzymes and production of malondialdehyde from cell membranes were differently regulated following treatment with either Orn enantiomer. The results suggest that management of H2O2 content is a determining feature of the function of Orn enantiomers in tobacco cells under salinity and drought stress conditions. Chirality 25:583–588, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
4.
5.
Biodiversity and Conservation - Palaeoecology is increasingly contributing to conservation biology and restoration ecology by extending the recent annual to decennial records of ecological... 相似文献
6.
Tabaei Samira Motallebnezhad Morteza Tabaee Seyedeh Samaneh 《Biochemical genetics》2021,59(4):813-836
Biochemical Genetics - Several studies have noted that vitamin D receptor (VDR) gene polymorphisms are involved in the susceptibility to Coronary artery disease (CAD). Nonetheless, the results have... 相似文献
7.
Rahmani Behrouz Ghashghayi Elham Zendehdel Morteza Khodadadi Mina Hamidi Behnam 《International journal of peptide research and therapeutics》2021,27(4):2349-2370
International Journal of Peptide Research and Therapeutics - Appetite is controlled by a complex system of central and peripheral signals interacting to modulate the ingestion response. Several... 相似文献
8.
Moosadoost Yasaman Zendehdel Morteza Khodadadi Mina 《International journal of peptide research and therapeutics》2021,27(1):253-262
International Journal of Peptide Research and Therapeutics - RFamide-related Peptide-3(RFRP-3) plays a key role in appetite regulation. The current study aimed to determine the effect of... 相似文献
9.
Masoumeh Shayanmehr Elliyeh Yahyapour Morteza Kahrarian Elham Yoosefi Lafooraki 《ZooKeys》2013,(335):69-83
The Collembola fauna of Iran is little known and no comprehensive examination of this group of Hexapoda is available for this region. The only notable work on Collembola was carried out by Cox (1982). Recently, studies on the Collembola fauna have started in several regions. In this paper, publications by different researchers are documented and the species that have been found in different regions of Iran until January 2013 are listed. At present, 112 species, belonging to 18 families and 57 genera are known from Iran. 相似文献
10.
Ahad Ferdowsi Khosroshahi Jafar Soleimani Rad Razie Kheirjou Babak Roshangar Morteza Rashtbar Roya Salehi Mohammad Reza Ranjkesh Leila Roshangar 《Journal of cellular physiology》2020,235(2):1556-1567
The extracellular matrix of different mammalian tissues is commonly used as scaffolds in the field of tissue engineering. One of these tissues, which has frequently been studied due to its structural and biological features, is the small intestine submucosal membrane. These research are mainly done on the porcine small intestine. However, a report has recently been published about a scaffold produced from the submucosal layer of the ovine small intestine. In the present study, ovine small intestine submucosal (OSIS) was decellularized in a modified manner and its histological, morphological, and biomechanical properties were studied. Decellularization was performed in two phases: physical and chemical. In this method, a chloroform-methanol mixture, enzymatic digestion, and a constant dose of sodium dodecyl sulfate (SDS) was used in the least agitation time and its histological property and biocompatibility were evaluated in the presence of adipose tissue-derived stem cells (ADSCs); furthermore, ADSCs were isolated with a simple method (modified physical washing non-enzymatic isolation). The results were showed that the use of OSIS could be effective and operative. Mechanical properties, histological structure and shape, and glycosaminoglycan content were preserved. In the SDS-treated group, more than 90% of the native cells of tissue were deleted, and also in this group, no toxicity was observed and cell proliferation was supported, compared to the untreated group. Therefore, our results indicate that ADSCs seeded on OSIS scaffold could be used as a new approach in regenerative medicine as hybrid or hydrogel application. 相似文献