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排序方式: 共有131条查询结果,搜索用时 609 毫秒
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Localization of gamma-glutamyl transpeptidase in lymphoid cells 总被引:1,自引:0,他引:1
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Bansal Mitaly Adamski Nikolai M. Toor Puneet Inder Kaur Satinder Sharma Achla Srivastava Puja Bansal Urmil Uauy Cristobal Chhuneja Parveen 《Molecular biology reports》2021,48(6):5209-5216
Molecular Biology Reports - Stripe rust and leaf rust are among the most devastating diseases of wheat, limiting its production globally. Wheat wild relatives harbour genetic diversity for new... 相似文献
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Gupta Achla Gullapalli Srinivas Pan Hui Ramos-Ortolaza Dinah L. Hayward Michael D. Low Malcom J. Pintar John E. Devi Lakshmi A. Gomes Ivone 《Cellular and molecular neurobiology》2021,41(5):1103-1118
Cellular and Molecular Neurobiology - Activation of μ, δ, and κ opioid receptors by endogenous opioid peptides leads to the regulation of many emotional and physiological responses.... 相似文献
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Chunjian Liu James Lin Gerry Everlof Christoph Gesenberg Hongjian Zhang Punit H. Marathe Mary Malley Michael A. Galella Murray Mckinnon John H. Dodd Joel C. Barrish Gary L. Schieven Katerina Leftheris 《Bioorganic & medicinal chemistry letters》2013,23(10):3028-3033
A series of carbamoylmethylene linked prodrugs of 1 (BMS-582949), a clinical p38α inhibitor, were synthesized and evaluated. Though the phosphoryloxymethylene carbamates (3, 4, and 5) and α-aminoacyloxymethylene carbamates (22, 23, and 26) were found unstable at neutral pH values, fumaric acid derived acyloxymethylene carbamates (2, 28, and 31) were highly stable under both acidic and neutral conditions. Prodrugs 2 and 31 were also highly soluble at both acidic and neutral pH values. At a solution dose of 14.2 mpk (equivalent to 10 mpk of 1), 2 gave essentially the same exposure of 1 compared to dosing 10 mpk of 1 itself. At a suspension dose of 142 mpk (equivalent to 100 mpk of 1), 2 demonstrated that it could overcome the solubility issue associated with 1 and provide a much higher exposure of 1. To our knowledge, the unique type of prodrugs like 2, 28, and 31 was not reported in the past and could represent a novel prodrug approach for secondary amides, a class of molecules frequently identified as drug candidates. 相似文献
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Elaine O. Nsoesie Richard J. Beckman Sara Shashaani Kalyani S. Nagaraj Madhav V. Marathe 《PloS one》2013,8(6)
Reliable forecasts of influenza can aid in the control of both seasonal and pandemic outbreaks. We introduce a simulation optimization (SIMOP) approach for forecasting the influenza epidemic curve. This study represents the final step of a project aimed at using a combination of simulation, classification, statistical and optimization techniques to forecast the epidemic curve and infer underlying model parameters during an influenza outbreak. The SIMOP procedure combines an individual-based model and the Nelder-Mead simplex optimization method. The method is used to forecast epidemics simulated over synthetic social networks representing Montgomery County in Virginia, Miami, Seattle and surrounding metropolitan regions. The results are presented for the first four weeks. Depending on the synthetic network, the peak time could be predicted within a 95% CI as early as seven weeks before the actual peak. The peak infected and total infected were also accurately forecasted for Montgomery County in Virginia within the forecasting period. Forecasting of the epidemic curve for both seasonal and pandemic influenza outbreaks is a complex problem, however this is a preliminary step and the results suggest that more can be achieved in this area. 相似文献
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