全文获取类型
收费全文 | 1577011篇 |
免费 | 221243篇 |
国内免费 | 30444篇 |
出版年
2018年 | 16519篇 |
2017年 | 15559篇 |
2016年 | 21893篇 |
2015年 | 30361篇 |
2014年 | 34713篇 |
2013年 | 48281篇 |
2012年 | 54366篇 |
2011年 | 54733篇 |
2010年 | 38867篇 |
2009年 | 38872篇 |
2008年 | 49450篇 |
2007年 | 50602篇 |
2006年 | 46434篇 |
2005年 | 44884篇 |
2004年 | 44687篇 |
2003年 | 42647篇 |
2002年 | 41968篇 |
2001年 | 64841篇 |
2000年 | 63662篇 |
1999年 | 54165篇 |
1998年 | 24313篇 |
1997年 | 23608篇 |
1996年 | 22167篇 |
1995年 | 21467篇 |
1994年 | 20805篇 |
1993年 | 20392篇 |
1992年 | 45451篇 |
1991年 | 44165篇 |
1990年 | 43547篇 |
1989年 | 42403篇 |
1988年 | 39355篇 |
1987年 | 37380篇 |
1986年 | 34973篇 |
1985年 | 35006篇 |
1984年 | 29237篇 |
1983年 | 25258篇 |
1982年 | 20439篇 |
1981年 | 18459篇 |
1980年 | 17482篇 |
1979年 | 28079篇 |
1978年 | 22317篇 |
1977年 | 20456篇 |
1976年 | 19117篇 |
1975年 | 20681篇 |
1974年 | 22669篇 |
1973年 | 22579篇 |
1972年 | 20471篇 |
1971年 | 18937篇 |
1970年 | 16400篇 |
1969年 | 15881篇 |
排序方式: 共有10000条查询结果,搜索用时 625 毫秒
1.
2.
M Shadidy X Caubit R Olsen O M Seternes U Moens S Krauss 《Biochimica et biophysica acta》1999,1446(3):295-307
We have identified mouse and human FKBP60, a new member of the FKBP gene family. FKBP60 shares strongest homology with FKBP65 and SMAP. FKBP60 contains a hydrophobic signal peptide at the N-terminus, 4 peptidyl-prolyl cis/trans isomerase (PPIase) domains and an endoplasmic reticulum retention motif (HDEL) at the C-terminus. Immunodetection of HA-tagged FKBP60 in NIH-3T3 cells suggests that FKBP60 is segregated to the endoplasmic reticulum. Northern blot analysis shows that FKBP60 is predominantly expressed in heart, skeletal muscle, lung, liver and kidney. With N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as a substrate, recombinant GST-FKBP60 is shown to accelerate effectively the isomerization of the peptidyl-prolyl bond. This isomerization activity is inhibited by FK506. mFKBP60 binds Ca2+ in vitro, presumably by its C-terminal EF-hand Ca2+ binding motif, and is phosphorylated in vivo. hFKBP60 has been mapped to 7p12 and/or 7p14 by fluorescence in situ hybridization (FISH). 相似文献
3.
4.
5.
Squilla mantis hemocyanin is composed of two hexameric subunits but has electron microscopic profiles different from other bis-hexameric hemocyanins, e.g. Astacus and Homarus. We distinguished three different electron microscopic profiles of S. mantis hemocyanin: two sideviews and a topview. These profiles were studied using computer image alignment and correspondence analysis [Van Heel, M. and Frank, J. (1981) Ultramicroscopy 6, 187 - 194]. With the results of this analysis we were able to build a three-dimensional model for the quaternary structure of this hemocyanin. In this model the two hexamers are stacked in such a way that their hexagonal surfaces overlap to about 60% of their width. In the overlap area four subunits are arranged in two different interhexameric pairs, each forming a bridging area between the two hexamers. 相似文献
6.
7.
8.
A patient with chronic anemia is presented who radiologically showed prominent rugae of the stomach. Angiography demonstrated an arteriovenous malformation with a large feeding artery and prominent draining veins. 相似文献
9.
10.