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Peter D. Moyes 《CMAJ》1966,94(1):13-18
The advantages, methods and results of surgical intracranial obliteration of aneurysms in conjunction with the use of intracranial or neck ligation of arteries were studied in 177 patients made up of the following groups: (a) internal carotid aneurysms-48, (b) anterior cerebral-anterior communicating-37, (c) middle cerebral-20, (b) basilar-two, (e) posterior cerebral-one. The overall mortality rate was 23%. Following conservative treatment, 69 patients with subarachnoid hemorrhage without demonstrated aneurysms had a mortality rate of 30%. In this seven-year study the value of team work involving a second neurosurgeon, well-trained nursing personnel and expert anesthetists was amply demonstrated. 相似文献
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Semi-arid ecosystems with annual moisture inputs dominated by snowmelt cover much of the western United States, and a better understanding of their seasonal drivers of soil respiration is needed to predict consequences of climatic change on soil CO2 efflux. We assessed the relative importance of temperature, moisture, and plant phenology on soil respiration during seasonal shifts between cold, wet winters and hot, dry summers in a Rocky Mountain meadow over 3.5 separate growing seasons. We found a consistent, unique pattern of seasonal hysteresis in the annual relationship between soil respiration and temperature, likely representative for this ecosystem type, and driven by (1) continued increase in soil T after summer senescence of vegetation, and (2) reduced soil respiration during cold, wet periods at the beginning versus end of the growing season. The timing of meadow senescence varied between years with amount of cold season precipitation, but on average occurred 45 days before soil temperature peaked in late-summer. Autumn soil respiration was greatest when substantial autumn precipitation events occurred early. Surface CO2 efflux was temporarily decoupled from respiratory production during winter 2006/2007, due to effects of winter surface snow and ice on mediating the diffusion of CO2 from deep soil horizons to the atmosphere. Upon melt of a capping surface ice layer, release of soil-stored CO2 was determined to be 65 g C, or ~10 % of the total growing season soil respiration for that year. The shift between soil respiration sources arising from moisture-limited spring plant growth and autumn decomposition indicates that annual mineralization of soil carbon will be less dependent on projected changes in temperature than on future variations in amount and timing of precipitation for this site and similar semi-arid ecosystems. 相似文献
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Simon I. Hay Katherine E. Battle David M. Pigott David L. Smith Catherine L. Moyes Samir Bhatt John S. Brownstein Nigel Collier Monica F. Myers Dylan B. George Peter W. Gething 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2013,368(1614)
The primary aim of this review was to evaluate the state of knowledge of the geographical distribution of all infectious diseases of clinical significance to humans. A systematic review was conducted to enumerate cartographic progress, with respect to the data available for mapping and the methods currently applied. The results helped define the minimum information requirements for mapping infectious disease occurrence, and a quantitative framework for assessing the mapping opportunities for all infectious diseases. This revealed that of 355 infectious diseases identified, 174 (49%) have a strong rationale for mapping and of these only 7 (4%) had been comprehensively mapped. A variety of ambitions, such as the quantification of the global burden of infectious disease, international biosurveillance, assessing the likelihood of infectious disease outbreaks and exploring the propensity for infectious disease evolution and emergence, are limited by these omissions. An overview of the factors hindering progress in disease cartography is provided. It is argued that rapid improvement in the landscape of infectious diseases mapping can be made by embracing non-conventional data sources, automation of geo-positioning and mapping procedures enabled by machine learning and information technology, respectively, in addition to harnessing labour of the volunteer ‘cognitive surplus’ through crowdsourcing. 相似文献
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Badgers prefer cattle pasture but avoid cattle: implications for bovine tuberculosis control
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Rosie Woodroffe Christl A. Donnelly Cally Ham Seth Y. B. Jackson Kelly Moyes Kayna Chapman Naomi G. Stratton Samantha J. Cartwright 《Ecology letters》2016,19(10):1201-1208
Effective management of infectious disease relies upon understanding mechanisms of pathogen transmission. In particular, while models of disease dynamics usually assume transmission through direct contact, transmission through environmental contamination can cause different dynamics. We used Global Positioning System (GPS) collars and proximity‐sensing contact‐collars to explore opportunities for transmission of Mycobacterium bovis [causal agent of bovine tuberculosis] between cattle and badgers (Meles meles). Cattle pasture was badgers’ most preferred habitat. Nevertheless, although collared cattle spent 2914 collar‐nights in the home ranges of contact‐collared badgers, and 5380 collar‐nights in the home ranges of GPS‐collared badgers, we detected no direct contacts between the two species. Simultaneous GPS‐tracking revealed that badgers preferred land > 50 m from cattle. Very infrequent direct contact indicates that badger‐to‐cattle and cattle‐to‐badger M. bovis transmission may typically occur through contamination of the two species’ shared environment. This information should help to inform tuberculosis control by guiding both modelling and farm management. 相似文献
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Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase
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Sharon C Mithoe Christina Ludwig Michiel JC Pel Mara Cucinotta Alberto Casartelli Malick Mbengue Jan Sklenar Paul Derbyshire Silke Robatzek Corné MJ Pieterse Ruedi Aebersold Frank LH Menke 《EMBO reports》2016,17(3):441-454
Pattern recognition receptors (PRRs) play a key role in plant and animal innate immunity. PRR binding of their cognate ligand triggers a signaling network and activates an immune response. Activation of PRR signaling must be controlled prior to ligand binding to prevent spurious signaling and immune activation. Flagellin perception in Arabidopsis through FLAGELLIN‐SENSITIVE 2 (FLS2) induces the activation of mitogen‐activated protein kinases (MAPKs) and immunity. However, the precise molecular mechanism that connects activated FLS2 to downstream MAPK cascades remains unknown. Here, we report the identification of a differentially phosphorylated MAP kinase kinase kinase that also interacts with FLS2. Using targeted proteomics and functional analysis, we show that MKKK7 negatively regulates flagellin‐triggered signaling and basal immunity and this requires phosphorylation of MKKK7 on specific serine residues. MKKK7 attenuates MPK6 activity and defense gene expression. Moreover, MKKK7 suppresses the reactive oxygen species burst downstream of FLS2, suggesting that MKKK7‐mediated attenuation of FLS2 signaling occurs through direct modulation of the FLS2 complex. 相似文献
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Nicholas J. Gotelli Faye Moyes Laura H. Anto Shane A. Blowes Maria Dornelas Brian J. McGill Amelia Penny Aafke M. Schipper Hideyasu Shimadzu Sarah R. Supp Conor A. Waldock Anne E. Magurran 《Global Change Biology》2022,28(1):46-53
The species composition of plant and animal assemblages across the globe has changed substantially over the past century. How do the dynamics of individual species cause this change? We classified species into seven unique categories of temporal dynamics based on the ordered sequence of presences and absences that each species contributes to an assemblage time series. We applied this framework to 14,434 species trajectories comprising 280 assemblages of temperate marine fishes surveyed annually for 20 or more years. Although 90% of the assemblages diverged in species composition from the baseline year, this compositional change was largely driven by only 8% of the species' trajectories. Quantifying the reorganization of assemblages based on species shared temporal dynamics should facilitate the task of monitoring and restoring biodiversity. We suggest ways in which our framework could provide informative measures of compositional change, as well as leverage future research on pattern and process in ecological systems. 相似文献