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Biophysics - Abstract—A study was conducted to explore the characteristics of the dependence of the contraction force (isometric mode at 30°C) on the frequency of stimulation... 相似文献
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A.?S.?AverinEmail author L.?S.?Kosarsky S.?V.?Tarlachkov V.?A.?Vekhnik I.?V.?Averina A.?E.?Alekseev E.?E.?Fesenko O.?V.?Nakipova 《Biophysics》2017,62(1):109-114
We investigated the effect of KB-R7943, an inhibitor of the reverse mode of Na+/Ca2+ exchanger, on the force of isometric contractions, the contractile force–frequency relationship and post-rest potentiation (a qualitative parameter of Ca2+ levels in sarcoplasmic reticulum) in the right ventricle papillary muscles isolated from ground squirrel hearts during summer (June, n = 4) and autumn (October, n = 4) activities. In the presence of 1.8 mM Ca2+at 36°C, 1–1.5 hours-long treatment of the summer papillary muscles with KB-R7943 produced no significant effects on the contractile indices at the majority of stimulation frequencies. In the autumn papillary muscles KB-R7943 induced a 40–50% decrease in the force of contraction (negative inotropic effect) at low stimulation frequencies (0.1–0.3 Hz) without any significant effect at higher stimulation frequencies (0.4–3.0 Hz). Furthermore, in this group, KB-R7943 suppressed the post-rest potentiation of contractility by 50 ± 21% at pause durations exceeding 120 s. These observations indicate that KB-R7943 can affect Ca2+ levels in sarcoplasmic reticulum and that Na+/Ca2+ exchange may contribute to the physiological remodeling of intracellular Ca2+ homeostasis in myocardium of hibernating animals prior their transition to a hypometabolic torpid state. 相似文献
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Averin A. S. Nakipova O. V. Kosarsky L. S. Pimenov O. Yu. Galimova M. H. Nenov M. N. Berejnov A. V. Alekseev A. E. 《Biophysics》2019,64(5):793-798
Biophysics - Abstract—The body’s response to stress is mediated by the interaction of catecholamines with adrenergic α- and β-receptors. It has been established that, in... 相似文献
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