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Zoe-Dorothea Pana Aspasia Katragkou Emmanuel Roilides 《Current fungal infection reports》2011,5(3):141-150
Fungal infections remain a serious clinical problem with a high disease and financial burden, especially among immunocompromised
and critically ill patients. Numerous efforts have not fully identified clinical and laboratory risk factors for increased
susceptibility to fungal infections. The recent acquisition of knowledge about innate immune responses to fungi and genetic
alterations in immunologic mechanisms has revealed additional genetic risk factors and has shed more light on the predisposition
of individuals to fungal infections. The aim of this review is to address the findings of recent studies associating genetic
factors with susceptibility to fungal infections, focusing on the most common opportunistic fungi, Candida and Aspergillus species. 相似文献
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Vogiatzi Lambrini Katragkou Aspasia Roilides Emmanuel 《Current fungal infection reports》2013,7(4):361-371
Invasive fungal infections in children have shown a dramatic increase over the last two decades. Their importance and clinical implications are more prominent in selected groups of patients such as critically ill children in the pediatric intensive care unit (PICU). This population constitutes an important target for prophylactic antifungal interventions. While antifungal agents have been studied in various clinical settings, knowledge in this particular setting is rather scant. The current data suggest that antifungal prophylaxis in the PICU setting should be tailored to the needs of each patient guided by the individual’s risk factors and local epidemiology.
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Katragkou A Simitsopoulou M Chatzimoschou A Georgiadou E Walsh TJ Roilides E 《Cytokine》2011,55(3):330-334
Candida albicans is a leading cause of biofilm-related infections. As Candida biofilms are recalcitrant to host defenses, we sought to determine the effects of interferon-γ and granulocyte colony-stimulating factor, two pro-inflammatory cytokines, on the antifungal activities of human polymorphonuclear neutrophils (PMNs) against C. albicans biofilms, using an in vitro biofilm model. Priming of PMNs by these cytokines augmented fungal damage of planktonic cells; however, priming of PMNs did not have the same effect against Candida biofilms. Biofilm phenotype appears to play an important role in protecting C. albicans from the innate immune system. 相似文献
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