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本文报道在云南省昆明市华山松(Pinus armandi Franch.)上发现的斑痣盘菌科一新种,即松生小鞋孢盘菌(Soleella pinicola Y.R.Lin et W.Ren)。对该种作了拉丁文、汉文描述和图解。主模式标本保藏于安徽农学院林学系森林保护教研室。 相似文献
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The objective of this study was to investigate the relationship between in vitro permeability (Papp) values obtained from isolated nasal tissues and the absorption rates (ka) of the same compounds following nasal administration in animals and humans. The Papp of a set of 11 drug compounds was measured using animal nasal explants and plasma time–concentration profiles for each of the same compounds following intravenous (IV) and intranasal (IN) administration were experimentally determined or obtained from literature reports. The plasma clearance was estimated from the IV plasma time–concentration profiles, and ka was determined from the IN plasma time–concentration profiles using a deconvolution approach. The level of correlation between Papp and ka was established using Pearson correlation analysis. A good correlation (r = 0.77) representing a point-to-point relationship for each of the compounds was observed. This result indicates that the nasal absorption for many drug candidates can be estimated from a readily measured in vitro Papp value.Key words: bioavailability, drug transport, nasal administration, nasal mucosa, permeability 相似文献
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新疆温泉煤田早、中侏罗世孢粉组合及其地层意义* 总被引:15,自引:4,他引:15
新疆温泉煤田艾肯拜尔段和柯克它乌组的孢粉化石,计有42属59种.根据孢粉类型和含量变化等特征,建立2个孢粉组合(自下而上):1. Dictyophyllidites-Chordasporites-Jugasporites 组合;2. Cyathidites-Neoraistrickia-Pseudopicea 组合.第一组合产于艾肯拜尔段,时代可能为早侏罗世,第二组合产于柯克它乌组,时代暂定为早、中侏罗世.根据孢粉组合反映的植物群面貌是:裸子植物非常茂盛,其中以松柏纲为主,蕨类植物较少(包括真蕨纲植物);反映的古气候属于温暖湿润的亚热带型. 相似文献
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本文报导了金蛇王营养液(GKS)对老龄鼠细胞因子产生的影响。实验表明,细胞因子分泌功能下降的老龄鼠饲喂金蛇王营养液后,IL-2和IFN-r水平明显增加。进而证明金蛇王营养液是一种良好的免疫增强剂,能增强老龄机体抗肿瘤、抗感染等作用 相似文献
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棕色棉与白色棉缩合单宁单体儿茶素动态变化的比较 总被引:2,自引:0,他引:2
以棕色棉ANL-1’和白色棉‘泗棉3号’为材料,利用HPLc检测棉纤维发育过程中儿茶素的动态变化,结果表明:棉种皮中的儿茶素含量高于棉纤维中的,各种儿茶素单体(EGC、C、EC、EGCG、GCG、ECG、cG)的含量在花后30d迅速下降,其中在白色棉纤维中的下降幅度最大;棕色棉和白色棉发育期棉纤维中儿茶素存在很大差异,如棕色棉纤维中有Ec、CG,但在白色棉纤维中却没有发现。初步推断棕色棉与白色棉纤维中缩合单宁结构有较大不同,可能导致棉纤维颜色发生差异。 相似文献
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Hefei Zhang Binfeng Xia Jennifer Sheng Tycho Heimbach Tsu-Han Lin Handan He Yanfeng Wang Steven Novick Ann Comfort 《AAPS PharmSciTech》2014,15(2):400-406
Physiologically based pharmacokinetic (PBPK) modeling has been broadly used to facilitate drug development, hereby we developed a PBPK model to systematically investigate the underlying mechanisms of the observed positive food effect of compound X (cpd X) and to strategically explore the feasible approaches to mitigate the food effect. Cpd X is a weak base with pH-dependent solubility; the compound displays significant and dose-dependent food effect in humans, leading to a nonadherence of drug administration. A GastroPlus Opt logD Model was selected for pharmacokinetic simulation under both fasted and fed conditions, where the biopharmaceutic parameters (e.g., solubility and permeability) for cpd X were determined in vitro, and human pharmacokinetic disposition properties were predicted from preclinical data and then optimized with clinical pharmacokinetic data. A parameter sensitivity analysis was performed to evaluate the effect of particle size on the cpd X absorption. A PBPK model was successfully developed for cpd X; its pharmacokinetic parameters (e.g., C max, AUCinf, and t max) predicted at different oral doses were within ±25% of the observed mean values. The in vivo solubility (in duodenum) and mean precipitation time under fed conditions were estimated to be 7.4- and 3.4-fold higher than those under fasted conditions, respectively. The PBPK modeling analysis provided a reasonable explanation for the underlying mechanism for the observed positive food effect of the cpd X in humans. Oral absorption of the cpd X can be increased by reducing the particle size (<100 nm) of an active pharmaceutical ingredient under fasted conditions and therefore, reduce the cpd X food effect correspondingly. 相似文献
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近年作者对我国北部12省(自治区、直辖市)松属(Pinus L.)植物上的斑痣盘菌目(Rhytismatales)真菌进行了分类研究。本文报道3属15种,其中连合散斑壳(Lophodermium confluens Lin,Hou & W.F.Zheng)是新种,斯塔雷散斑壳(Lophodermium staleyi Minter)为中国新记录种,小环绵盘菌[Cyclaneusma minus(Butin)DiCosmo,Peredo & Minter]和华山松舟皮盘菌(Ploioderma pini-armandii Hou et S.Q.Liu)等其余种为国内已知种。编制了分种检索表。对新种进行了拉丁文、汉文描述和图解,对新记录种的主要特点以及已知种的寄主国内外新记录、国内地理新分布和生态习性等分别作了记载。 相似文献