全文获取类型
收费全文 | 4221篇 |
免费 | 337篇 |
国内免费 | 2篇 |
出版年
2021年 | 52篇 |
2020年 | 38篇 |
2019年 | 45篇 |
2018年 | 54篇 |
2017年 | 48篇 |
2016年 | 72篇 |
2015年 | 128篇 |
2014年 | 166篇 |
2013年 | 224篇 |
2012年 | 272篇 |
2011年 | 258篇 |
2010年 | 187篇 |
2009年 | 171篇 |
2008年 | 230篇 |
2007年 | 245篇 |
2006年 | 228篇 |
2005年 | 226篇 |
2004年 | 200篇 |
2003年 | 187篇 |
2002年 | 167篇 |
2001年 | 82篇 |
2000年 | 69篇 |
1999年 | 79篇 |
1998年 | 63篇 |
1997年 | 49篇 |
1996年 | 41篇 |
1995年 | 48篇 |
1994年 | 53篇 |
1993年 | 32篇 |
1992年 | 45篇 |
1991年 | 58篇 |
1990年 | 44篇 |
1989年 | 44篇 |
1988年 | 33篇 |
1987年 | 29篇 |
1986年 | 37篇 |
1985年 | 27篇 |
1984年 | 50篇 |
1983年 | 46篇 |
1982年 | 33篇 |
1981年 | 29篇 |
1980年 | 23篇 |
1979年 | 18篇 |
1978年 | 26篇 |
1977年 | 22篇 |
1976年 | 19篇 |
1975年 | 23篇 |
1974年 | 27篇 |
1973年 | 24篇 |
1971年 | 18篇 |
排序方式: 共有4560条查询结果,搜索用时 46 毫秒
1.
2.
3.
4.
Vincent Anquetil Caroline Le Sommer Agn��s M��reau Sandra Hamon Hubert Lerivray Serge Hardy 《The Journal of biological chemistry》2009,284(47):32370-32383
Alternative splicing of 3′-terminal exons plays a critical role in gene expression by producing mRNA with distinct 3′-untranslated regions that regulate their fate and their expression. The Xenopus α-tropomyosin pre-mRNA possesses a composite internal/3′-terminal exon (exon 9A9′) that is differentially processed depending on the embryonic tissue. Exon 9A9′ is repressed in non-muscle tissue by the polypyrimidine tract binding protein, whereas it is selected as a 3′-terminal or internal exon in myotomal cells and adult striated muscles, respectively. We report here the identification of an intronic regulatory element, designated the upstream terminal exon enhancer (UTE), that is required for the specific usage of exon 9A9′ as a 3′-terminal exon in the myotome. We demonstrate that polypyrimidine tract binding protein prevents the activity of UTE in non-muscle cells, whereas a subclass of serine/arginine rich (SR) proteins promotes the selection of exon 9A9′ in a UTE-dependent way. Morpholino-targeted blocking of UTE in the embryo strongly reduced the inclusion of exon 9A9′ as a 3′-terminal exon in the endogenous mRNA, demonstrating the function of UTE under physiological circumstances. This strategy allowed us to reveal a splicing pathway that generates a mRNA with no in frame stop codon and whose steady-state level is translation-dependent. This result suggests that a non-stop decay mechanism participates in the strict control of the 3′-end processing of the α-tropomyosin pre-mRNA. 相似文献
5.
6.
7.
The Saharan silver ant Cataglyphis bombycina is one of the terrestrial living organisms best adapted to tolerate high temperatures. It has recently been shown that the hairs covering the ant’s dorsal body part are responsible for its silvery appearance. The hairs have a triangular cross-section with two corrugated surfaces allowing a high optical reflection in the visible and near-infrared (NIR) range of the spectrum while maximizing heat emissivity in the mid-infrared (MIR). Those two effects account for remarkable thermoregulatory properties, enabling the ant to maintain a lower thermal steady state and to cope with the high temperature of its natural habitat. In this paper, we further investigate how geometrical optical and high reflection properties account for the bright silver color of C. bombycina. Using optical ray-tracing models and attenuated total reflection (ATR) experiments, we show that, for a large range of incidence angles, total internal reflection (TIR) conditions are satisfied on the basal face of each hair for light entering and exiting through its upper faces. The reflection properties of the hairs are further enhanced by the presence of the corrugated surface, giving them an almost total specular reflectance for most incidence angles. We also show that hairs provide an almost 10-fold increase in light reflection, and we confirm experimentally that they are responsible for a lower internal body temperature under incident sunlight. Overall, this study improves our understanding of the optical mechanisms responsible for the silver color of C. bombycina and the remarkable thermoregulatory properties of the hair coat covering the ant’s body. 相似文献
8.
9.
10.