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Altinoz Meric A. Topcu Gulacti Hacimuftuoglu Ahmet Ozpinar Alp Ozpinar Aysel Hacker Emily Elmaci İlhan 《Neurochemical research》2019,44(8):1796-1806
Neurochemical Research - Noscapine is a phthalide isoquinoline alkaloid that easily traverses the blood brain barrier and has been used for years as an antitussive agent with high safety. Despite... 相似文献
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Turkmen Z Klymchenko AS Oncul S Duportail G Topcu G Demchenko AP 《Journal of biochemical and biophysical methods》2005,64(1):1-18
We report on the synthesis by coupling of a triterpenoid oleanolic acid with 4'-diethylamino-3-hydroxyflavone (FE) to produce an environment-sensitive biomembrane probe with two-band ratiometric response in fluorescence emission. The synthesized compound (probe FOT) was tested in a series of model solvents and demonstrated the response to solvent polarity and intermolecular hydrogen bonding very similar to that of parent probe FE. Meantime when incorporated into lipid bilayer membranes, it showed new features differing in response between lipids of different surface charges as well as between glycerophospholipids and sphingomyelin. We observed that in the conditions of coexistence of rafts and non-raft structures the probe is excluded from the rafts. 相似文献
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