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排序方式: 共有984条查询结果,搜索用时 15 毫秒
1.
G J Ebrahim 《BMJ (Clinical research ed.)》1987,295(6608):1222-1223
2.
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases. 总被引:101,自引:0,他引:101
E Y Skolnik B Margolis M Mohammadi E Lowenstein R Fischer A Drepps A Ullrich J Schlessinger 《Cell》1991,65(1):83-90
A novel method has been developed to allow cloning of protein targets for receptors with tyrosine kinase activity. By utilizing the carboxy-terminal tail of EGF receptor (EGFR) as a probe to screen lambda gt11 expression libraries, several EGFR-binding proteins have been cloned; two have been analyzed and contain unique SH2 and SH3 domains. One gene (GRB-1) has been fully sequenced, is expressed in various tissues and cell lines, and has a molecular mass of 85 kd. Interestingly, GRB-1 encodes the human counterpart of the PI3 kinase-associated protein p85. Advantages of this technique include the ease of cloning tyrosine kinase receptor targets present at low levels and the ability to identify proteins that are related in their capacity to bind activated receptors but contain no significant DNA sequence homology. This method, termed CORT (for cloning of receptor targets), offers a general approach for the identification and cloning of various receptor targets. 相似文献
3.
Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. 总被引:27,自引:6,他引:21
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M Mohammadi I Dikic A Sorokin W H Burgess M Jaye J Schlessinger 《Molecular and cellular biology》1996,16(3):977-989
Fibroblast growth factor receptor (FGFR) activation leads to receptor autophosphorylation and increased tyrosine phosphorylation of several intra cellular proteins. We have previously shown that autophosphorylated tyrosine 766 in FGFR1 serves as a binding site for one of the SH2 domains of phospholipase Cy and couples FGFR1 to phosphatidylinositol hydrolysis in several cell types. In this report, we describe the identification of six additional autophosphorylation sites (Y-463, Y-583, Y-585, Y-653, Y-654 and Y-730) on FGFR1. We demonstrate that autophosphorylation on tyrosines 653 and 654 is important for activation of tyrosine kinase activity of FGFR1 and is therefore essential for FGFR1-mediated biological responses. In contrast, autophosphorylation of the remaining four tyrosines is dispensable for FGFR1-mediated mitogen-activated protein kinase activation and mitogenic signaling in L-6 cells as well as neuronal differentiation of PC12 cells. Interestingly, both the wild-type and a mutant FGFR1 (FGFR1-4F) are able to phosphorylate Shc and an unidentified Grb2-associated phosphoprotein of 90 kDa (pp90). Binding of the Grb2/Sos complex to phosphorylated Shc and pp90 may therefore be the key link between FGFR1 and the Ras signaling pathway, mito-genesis, and neuronal differentiation. 相似文献
4.
A Ebrahim F G Hamel R G Bennett W C Duckworth 《Biochemical and biophysical research communications》1991,181(3):1398-1406
Insulin degrading enzyme (IDE) is a thiol-dependent metalloendoprotease that is responsible for initiation of cellular insulin degradation. However, its exact mode of action and the factors controlling it are poorly understood. Since IDE is a metal requiring enzyme, we have examined which metal(s) is(are) endogenously associated with it. Using neutron activation analysis, we studied the metal content of a partially purified enzyme from three different tissues: rat skeletal muscle, rat liver, and human placenta. Our results indicate that zinc and manganese are associated with the enzyme with approximately 10 times more zinc as manganese being present. These results suggest that one or both of these two metals are endogenously associated with this enzyme and are a means of controlling the enzyme's activity. 相似文献
5.
Plasma Physics Reports - So far, the detailed experimental effect of the inductance on the X-ray yield in the Filippov-type plasma focus devices has not been documented in literature. In this... 相似文献
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Plasma Physics Reports - The effects of different nuclear reactions on thermonuclear burn-up conditions of equimolar mixture of deuterium–tritium are investigated. The minimum requirements... 相似文献
8.
Mehrizadeh Vahid Dorani Ebrahim Mohammadi Seyed Abolghasem Ghareyazie Behzad 《Plant Cell, Tissue and Organ Culture》2021,145(1):127-141
Plant Cell, Tissue and Organ Culture (PCTOC) - Globular androgenic haploid embryos of TV21 and TV19 cultivars of Camellia ssp., obtained on embryo induction medium (EIM), Murashige and Skoog medium... 相似文献
9.
Saremi Leila Shafizadeh Marziyeh Esmaeilzadeh Emran Ghaffari Mohammad Ebrahim Mahdavi Mohammad hosein Amid Reza Kadkhodazadeh Mahdi 《Molecular biology reports》2021,48(3):2285-2290
Molecular Biology Reports - Peri-implantitis (PI) is a multifactorial condition caused by the interactions of pathogens and the host immune response. Previous studies have demonstrated a... 相似文献
10.
Mirbolook Atena Rasouli-Sadaghiani MirHassan Sepehr Ebrahim Lakzian Amir Hakimi Mohammad 《Journal of Plant Growth Regulation》2021,40(2):831-847
Journal of Plant Growth Regulation - Plants require optimum amounts of nutrients for suitable growth and yield production. Accordingly, the most efficient methods of fertilization, including the... 相似文献